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Compounds that are candidates for drug repurposing can be ranked by leveraging knowledge available in the biomedical literature… Expand AIM
Mozavaptan is a nonpeptide vasopressin receptor antagonist approved for the treatment of ectopic antidiuretic hormone… Expand Rapid access to allylic trichloroacetimidates bearing a 2-allylaminoaryl group from readily available 2-iodoanilines combined… Expand Imidafenacin, an antimuscarinic agent for treating overactive bladder, has an antidiuretic effect, but the detailed mechanisms of… Expand Arginine vasopressin (AVP) is a 9-amino acid peptide that is secreted from the posterior pituitary in response to high plasma… Expand Small cell gall bladder carcinoma (Scc-GB) is a very rare entity. Although some cases present with endocrine manifestations… Expand BackgroundGiven the large medical burden of polycystic kidney disease (PKD) and recent clinical trial failures, there is a need… Expand The non-peptide vasopressin antagonists (VPA), called vaptans, were developed in the 1990s to antagonize both the pressor and… Expand Arginine-vasopressin is a hormone that plays an important part in circulatory and water homoeostasis. The three arginine… Expand Hypotonic hyponatraemia results from an excess of total body water relative to the exchangeable sodium and potassium pool due to… Expand