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motapizone

Known as: 4,5-dihydro-6-(4-(1H-imidazol-1-yl)-2-thienyl)-5-methyl-3(2H)-pyridazinone 
National Institutes of Health

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Related topics

1 relation

Broader (1)

Pyridazines

Papers overview

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Highly Cited
2000
Highly Cited
2000
Subthreshold doses of specific phosphodiesterase type 3 and 4 inhibitors enhance the pulmonary vasodilatory response to nebulized prostacyclin with improvement in gas exchange.
Aerosolized prostacyclin (PGI(2)) has been suggested for selective pulmonary vasodilation, but its effect rapidly levels off… 
Highly Cited
1999
Highly Cited
1999
Low-dose systemic phosphodiesterase inhibitors amplify the pulmonary vasodilatory response to inhaled prostacyclin in experimental pulmonary hypertension.
Inhalation of aerosolized prostaglandin I(2) (PGI(2)) causes selective pulmonary vasodilation, but the effect rapidly levels off… 
Highly Cited
1998
Highly Cited
1998
Phosphodiesterase profile of human B lymphocytes from normal and atopic donors and the effects of PDE inhibition on B cell proliferation
1 CD19+ B lymphocytes were purified from the peripheral blood of normal and atopic subjects to analyse and compare the… 
Review
1995
Review
1995
PDE isoenzymes as targets for anti-asthma drugs.
Phophodiesterase (PDE) isoenzyme profiles of human cell preparations and tissues have been analysed by a semiquantitative method… 
1995
1995
Effect of phosphodiesterase inhibition on IL-4 and IL-5 production of the murine TH2-type T cell clone D10.G4.1.
1995
1995
Activation of adenylate cyclase and phosphodiesterase inhibition enhance neutral endopeptidase activity in human endothelial cells
Highly Cited
1994
Highly Cited
1994
Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors.
The effects of the nonselective phosphodiesterase (PDE) inhibitor 3-isobutyl-1-methylxanthine (IBMX) and the selective PDE… 
Highly Cited
1993
Highly Cited
1993
The specific type III and IV phosphodiesterase inhibitor zardaverine suppresses formation of tumor necrosis factor by macrophages.
Highly Cited
1993
Highly Cited
1993
Role of phosphodiesterases in the regulation of endothelial permeability in vitro.
Neutrophil-derived hydrogen peroxide (H2O2) is believed to play an important role in the pathogenesis of vascular injury and… 
Review
1991
Review
1991
Zardaverine: a cyclic AMP specific PDE III/IV inhibitor.
Zardaverine is shown to inhibit selectively two out of five isoenzyme classes of phosphodiesterases, namely PDE III from human… 
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