morphogenesis of an epithelial fold
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ABSTRACT Epithelial folding shapes embryos and tissues during development. Here, we investigate the coupling between epithelial… Expand Epithelial folding (EF) is a fundamental morphogenetic process that can be observed in the development of many organisms ranging… Expand Epithelial folding is typically driven by localized actomyosin contractility. However, it remains unclear how epithelia deform… Expand During embryonic development, epithelial sheets fold into complex structures required for tissue and organ functions. Although… Expand Understanding the cellular and mechanical processes that underlie the shape changes of individual cells and their collective… Expand During tissue morphogenesis, simple epithelial sheets undergo folding to form complex structures. The prevailing model underlying… Expand The development of multicellular organisms relies on a small set of construction techniques-assembly, sculpting, and folding-that… Expand A single Rho GTPase family member is capable of initiating several different processes, including cell cycle regulation… Expand We present here a new model for epithelial morphogenesis, which we call the 'cortical tractor model'. This model assumes that the… Expand This review is concerned with the mechanical forces that cause epithelial sheets to invaginate during morphogenesis. Interest in… Expand