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mitotic checkpoint complex location

Known as: MCC, mitotic checkpoint complex 
A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this… 
National Institutes of Health

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mitotic checkpoint complex, CDC20-MAD2 subcomplex

Papers overview

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2019
2019
BubR1 Is Essential for Thio-Dimethylarsinic Acid-Induced Spindle Assembly Checkpoint and Mitotic Cell Death for Preventing the Accumulation of Abnormal Cells.
Thio-dimethylarsinic acid (thio-DMA) was detected in human urine after exposure to inorganic arsenic and arsenosugars consumed by… 
2017
2017
HDAC2/3 binding and deacetylation of BubR1 initiates spindle assembly checkpoint silencing
BubR1 acetylation is essential in spindle assembly checkpoint (SAC) signaling. Here we show that BubR1 deacetylation is a signal… 
2017
2017
The kinetochore-dependent and -independent formation of the CDC20-MAD2 complex and its functions in HeLa cells
The mitotic checkpoint complex (MCC) is formed from two sub-complexes of CDC20-MAD2 and BUBR1-BUB3, and current models suggest… 
2016
2016
Intermediates in the assembly of mitotic checkpoint complexes and their role in the regulation of the anaphase-promoting complex
Significance The mitotic checkpoint system has important roles to ensure accurate segregation of chromosomes in mitosis. This… 
Review
2016
Review
2016
Impact of Ado-trastuzumab Emtansine Therapy in Human Epidermal Growth Factor Receptor 2 Positive Metastatic Breast Cancer: A Recent Survey
Recent estimate revealed that in the year 2012, about 227,000 American women suffered from metastatic breast cancer (mBC). The U… 
2015
2015
Dual mechanism for APC/C activation by integrated ubiquitylation and dephosphorylation
The Anaphase Promoting Complex (APC/C) is a multi-subunit ubiquitin ligase that is essential for cell cycle progression. Ube2S… 
2010
2010
Purification of the mitotic checkpoint complex (MCC) and the anaphase promoting complex/cyclosome (APC/C) from HeLa cells.
In this protocol, active anaphase promoting complex/cyclosome (APC/C) and its inhibitor, mitotic checkpoint complex (MCC), are… 
2005
2005
Identification and purification of a soluble region of BubR1: a critical component of the mitotic checkpoint complex.
2005
2005
Post-translational regulation of Mad3p in Saccharomyces cerevisiae
Post-Translational Regulation of Mad3p in Saccharomyces cerevisiae The spindle checkpoint in eukaryotic cells maintains the… 
2004
2004
Purification of the mitotic checkpoint complex, an inhibitor of the APC/C from HeLa cells.
The mitotic checkpoint prevents cells with unaligned chromosomes from prematurely exiting mitosis by inhibiting the anaphase… 
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