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mitotic checkpoint complex location

Known as: MCC, mitotic checkpoint complex 
A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this… 
National Institutes of Health

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mitotic checkpoint complex, CDC20-MAD2 subcomplex

Papers overview

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2017
2017
HDAC2/3 binding and deacetylation of BubR1 initiates spindle assembly checkpoint silencing
BubR1 acetylation is essential in spindle assembly checkpoint (SAC) signaling. Here we show that BubR1 deacetylation is a signal… 
2017
2017
PTEN is a negative regulator of mitotic checkpoint complex during the cell cycle
Nuclear PTEN plays an important role during mitosis. To understand the molecular basis by which PTEN mediates mitotic progression… 
2017
2017
The kinetochore-dependent and -independent formation of the CDC20-MAD2 complex and its functions in HeLa cells
The mitotic checkpoint complex (MCC) is formed from two sub-complexes of CDC20-MAD2 and BUBR1-BUB3, and current models suggest… 
2016
2016
Intermediates in the assembly of mitotic checkpoint complexes and their role in the regulation of the anaphase-promoting complex
Significance The mitotic checkpoint system has important roles to ensure accurate segregation of chromosomes in mitosis. This… 
2016
2016
Synergistic inhibition of the APC/C by the removal of APC15 in HCT116 cells lacking UBE2C
ABSTRACT The spindle assembly checkpoint (SAC) inhibits the anaphase-promoting complex/cyclosome (APC/C) in response to… 
2016
2016
Mph1/MPS1 checks in at the kinetochore
The kinetochore is the major attachment site between chromosomes and microtubules during mitosis but also acts as the platform… 
2008
2008
Two different mitotic checkpoint inhibitors of the anaphase-promoting complex/cyclosome antagonize the action of the activator Cdc20
The mitotic checkpoint system ensures the fidelity of chromosome segregation by preventing the completion of mitosis in the… 
2005
2005
Large-scale purification of the vertebrate anaphase-promoting complex/cyclosome.
2005
2005
Identification and purification of a soluble region of BubR1: a critical component of the mitotic checkpoint complex.
2004
2004
Purification of the mitotic checkpoint complex, an inhibitor of the APC/C from HeLa cells.
The mitotic checkpoint prevents cells with unaligned chromosomes from prematurely exiting mitosis by inhibiting the anaphase… 
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