FAQ

mitoclomine

Known as: N,N-bis(2-chloroethyl)- 4-methoxy-3-methyl-1-naphthylamine, N,N-bis(2-chloroethyl)4-amino-2-methyl-1-methoxy-naphthalene 
An aromatic nitrogen mustard derivative with potential antineoplastic activity. Mitoclomine alkylates DNA and appears to concentrate primarily in the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1971-1990
0119711990

Related topics

Related topics

2 relations

Narrower (1)

NSC-114575

Broader (1)

Nitrogen Mustard Compounds

Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
mitoclomine
Nitrogen Mustard Compounds
NSC-114575

Papers overview

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1990
1990
Low density lipoprotein for delivery of a water-insoluble alkylating agent to malignant cells. In vitro and in vivo studies of a drug-lipoprotein complex.
Previous studies have shown that human leukaemic cells and certain tumour tissues have a higher receptor-mediated uptake of low… (More)
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1981
1981
Thymus-dependent and thymus-independent antibody responses: contrasting patterns of immunosuppression.
The effects of mitoclomine, an anti-tumour agent, and of cortisone acetate on the antibody response of mice to thymus-dependent… (More)
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1980
1980
Comparative physico-chemical properties, biological effects, and disposition in mice of four nitrogen mustards
Chlorambucil, phenyl acetic mustard, melphalan and mitoclomine are aromatic nitrogen mustard derivatives. These drugs show a… (More)
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1979
1979
Time-dependence and selectivity of immunosuppressive agents.
The effects of a variety of agents on the mouse antibody response to sheep red cells (SRC) and Escherichia coli… (More)
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1979
1979
[Relationship of labeled molecules in the pharmacokinetic study of alkylating agents (chlorambucil, melphalan, mitoclomine) and glycosyl nitrosoureas (RFCNU and RPCNU)].
 
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1978
1978
Disposition of a new alkylating agent [14C]mitoclomine (N,N-bis(2'-chloroethyl)4-amino-2-methyl-1-methoxy-naphthalene).
1. The absorption, distribution and elimination of a new alkylating agent, N,N-bis(2'-chloroethyl)4-amino-2-methyl-1… (More)
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1975
1975
Phase I-II clinical trial with mitoclomine (NSC-114575) in chronic lymphocytic leukemia.
 
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1971
1971
Investigations into the lymphopaenic and immunosuppressive properties of the antitumour agent, mitoclomine.
 
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