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mitoclomine

Known as: N,N-bis(2-chloroethyl)- 4-methoxy-3-methyl-1-naphthylamine, N,N-bis(2-chloroethyl)4-amino-2-methyl-1-methoxy-naphthalene 
An aromatic nitrogen mustard derivative with potential antineoplastic activity. Mitoclomine alkylates DNA and appears to concentrate primarily in the… Expand
National Institutes of Health

Related topics

Related topics

2 relations

Narrower (1)

NSC-114575

Broader (1)

Nitrogen Mustard Compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Br . J . exp . Path . ( 1981 ) 62 , 74 THYMUS-DEPENDENT AND THYMUS-INDEPENDENT ANTIBODY RESPONSES : CONTRASTING PATTERNS OF IMMUNOSUPPRESSION
  • I. E. ADDTSON, J. XV. B. BABBAGEt, Fronm
  • 2007
    • Corpus ID: 157062857
-The effects of mitochlomine, an anti-tumour agent, and of cortisone acetate on the antibody response of mice to thymus-dependent… Expand
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1990
1990
Low density lipoprotein for delivery of a water-insoluble alkylating agent to malignant cells. In vitro and in vivo studies of a drug-lipoprotein complex.
Previous studies have shown that human leukaemic cells and certain tumour tissues have a higher receptor-mediated uptake of low… Expand
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1981
1981
Thymus-dependent and thymus-independent antibody responses: contrasting patterns of immunosuppression.
The effects of mitoclomine, an anti-tumour agent, and of cortisone acetate on the antibody response of mice to thymus-dependent… Expand
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1980
1980
Comparative physico-chemical properties, biological effects, and disposition in mice of four nitrogen mustards
SummaryChlorambucil, phenyl acetic mustard, melphalan and mitoclomine are aromatic nitrogen mustard derivatives. These drugs show… Expand
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1979
1979
Time-dependence and selectivity of immunosuppressive agents.
The effects of a variety of agents on the mouse antibody response to sheep red cells (SRC) and Escherichia coli… Expand
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1979
1979
[Relationship of labeled molecules in the pharmacokinetic study of alkylating agents (chlorambucil, melphalan, mitoclomine) and glycosyl nitrosoureas (RFCNU and RPCNU)].
 
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1979
1979
L'apport des molecules marquees dans l'etude pharmacocinetique d'agents alkylants (chlorambucil, melphalan, mitoclomine) et de glycosyl nitrosourees (RFCNU et RPCNU).
 
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1978
1978
Disposition of a new alkylating agent [14C]mitoclomine (N,N-bis(2'-chloroethyl)4-amino-2-methyl-1-methoxy-naphthalene).
1. The absorption, distribution and elimination of a new alkylating agent, N,N-bis(2'-chloroethyl)4-amino-2-methyl-1… Expand
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1975
1975
Phase I-II clinical trial with mitoclomine (NSC-114575) in chronic lymphocytic leukemia.
Phase I-II trial of mitoclomine in chronic lymphocytic leukemia (CLL) is described. Twenty seven courses of mitoclomine were… Expand
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1971
1971
Investigations into the lymphopaenic and immunosuppressive properties of the antitumour agent, mitoclomine.
The formula of Mitoclomine (W.B. 7007) was suggested by Granger in 1966 (1) as that of a useful cytotoxic agent, and confirmed in… Expand
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