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mitoclomine

Known as: N,N-bis(2-chloroethyl)- 4-methoxy-3-methyl-1-naphthylamine, N,N-bis(2-chloroethyl)4-amino-2-methyl-1-methoxy-naphthalene 
An aromatic nitrogen mustard derivative with potential antineoplastic activity. Mitoclomine alkylates DNA and appears to concentrate primarily in the… Expand
National Institutes of Health

Related topics

Related topics

2 relations

Narrower (1)

NSC-114575

Broader (1)

Nitrogen Mustard Compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Br . J . exp . Path . ( 1981 ) 62 , 74 THYMUS-DEPENDENT AND THYMUS-INDEPENDENT ANTIBODY RESPONSES : CONTRASTING PATTERNS OF IMMUNOSUPPRESSION
-The effects of mitochlomine, an anti-tumour agent, and of cortisone acetate on the antibody response of mice to thymus-dependent… Expand
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2004
2004
Comparative physico-chemical properties, biological effects, and disposition in mice of four nitrogen mustards
SummaryChlorambucil, phenyl acetic mustard, melphalan and mitoclomine are aromatic nitrogen mustard derivatives. These drugs show… Expand
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1981
1981
Thymus-dependent and thymus-independent antibody responses: contrasting patterns of immunosuppression.
The effects of mitoclomine, an anti-tumour agent, and of cortisone acetate on the antibody response of mice to thymus-dependent… Expand
1979
1979
Time-dependence and selectivity of immunosuppressive agents.
The effects of a variety of agents on the mouse antibody response to sheep red cells (SRC) and Escherichia coli… Expand
1979
1979
L'apport des molecules marquees dans l'etude pharmacocinetique d'agents alkylants (chlorambucil, melphalan, mitoclomine) et de glycosyl nitrosourees (RFCNU et RPCNU).
 
1979
1979
[Relationship of labeled molecules in the pharmacokinetic study of alkylating agents (chlorambucil, melphalan, mitoclomine) and glycosyl nitrosoureas (RFCNU and RPCNU)].
 
1978
1978
Disposition of a new alkylating agent [14C]mitoclomine (N,N-bis(2'-chloroethyl)4-amino-2-methyl-1-methoxy-naphthalene).
1. The absorption, distribution and elimination of a new alkylating agent, N,N-bis(2'-chloroethyl)4-amino-2-methyl-1… Expand
1975
1975
Phase I-II clinical trial with mitoclomine (NSC-114575) in chronic lymphocytic leukemia.
Phase I-II trial of mitoclomine in chronic lymphocytic leukemia (CLL) is described. Twenty seven courses of mitoclomine were… Expand
1971
1971
Investigations into the lymphopaenic and immunosuppressive properties of the antitumour agent, mitoclomine.
The formula of Mitoclomine (W.B. 7007) was suggested by Granger in 1966 (1) as that of a useful cytotoxic agent, and confirmed in… Expand
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