mitochondrial permeability transition

Dysregulation of Ca(2+) has long been implicated to be important in cell injury. A Ca(2+)-linked process important in necrosis… Expand

Mitochondria play a critical role in mediating both apoptotic and necrotic cell death. The mitochondrial permeability transition… Expand

Mitochondria play an important role in energy production, Ca2+ homeostasis and cell death. In recent years, the role of the… Expand

Environmental stresses converge on the mitochondria that can trigger or inhibit cell death. Excitable, postmitotic cells, in… Expand

Acetaminophen overdose causes massive hepatic failure via mechanisms involving glutathione depletion, oxidative stress, and… Expand

Opening of high conductance permeability transition pores in mitochondria initiates onset of the mitochondrial permeability… Expand

Mitochondria play a key role in determining cell fate during exposure to stress. Their role during ischemia/reperfusion is… Expand

Cells degrade excess and effete organelles by the process of autophagy. Autophagic stimulation of rat hepatocytes by serum… Expand

We sought to understand the relationship between reactive oxygen species (ROS) and the mitochondrial permeability transition (MPT… Expand

Using confocal microscopy, onset of the mitochondrial permeability transition (MPT) in individual mitochondria within living… Expand