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mitochondrial DNA metabolic process

Known as: mitochondrial DNA metabolism, mtDNA metabolic process, mtDNA metabolism 
The chemical reactions and pathways involving mitochondrial DNA. [GOC:mah]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1976-2017
02419762017

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4 relations

Broader (2)

DNA metabolic processmitochondrial genome maintenance
Mitochondriaregulation of mitochondrial DNA metabolic process

Related mentions per year

Related mentions per year

1937-2018
19401960198020002020
mitochondrial DNA metabolic process
Mitochondria
DNA metabolic process
mitochondrial genome maintenance
regulation of mitochondrial DNA metabolic process

Papers overview

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2012
2012
Human mitochondrial DNA helicase TWINKLE is both an unwinding and annealing helicase.
TWINKLE is a nucleus-encoded human mitochondrial (mt)DNA helicase. Point mutations in TWINKLE are associated with heritable… (More)
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Highly Cited
2010
Highly Cited
2010
Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM).
Lon is the major protease in the mitochondrial matrix in eukaryotes, and is well conserved among species. Although a role for Lon… (More)
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2010
2010
Overexpression of MTERFD1 or MTERFD3 impairs the completion of mitochondrial DNA replication
The physiological roles of the mitochondrial transcription termination factor (mTERF) family are poorly understood. MTERF and its… (More)
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2009
2009
Mitochondrial localization of PARP-1 requires interaction with mitofilin and is involved in the maintenance of mitochondrial DNA integrity.
Poly(ADP-ribose)polymerase-1 (PARP-1) is a predominantly nuclear enzyme that exerts numerous functions in cellular physiology and… (More)
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2009
2009
The accessory subunit of mitochondrial DNA polymerase γ determines the DNA content of mitochondrial nucleoids in human cultured cells
The accessory subunit of mitochondrial DNA polymerase gamma, POLGbeta, functions as a processivity factor in vitro. Here we show… (More)
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2008
2008
Cisplatin-mediated impairment of mitochondrial DNA metabolism inversely correlates with glutathione levels.
Cisplatin accumulates in mitochondria, which are a major target for this drug in cancer cells. Thus alterations in mitochondrial… (More)
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Highly Cited
2007
Highly Cited
2007
Plant mitochondrial recombination surveillance requires unusual RecA and MutS homologs.
For >20 years, the enigmatic behavior of plant mitochondrial genomes has been well described but not well understood. Chimeric… (More)
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2006
2006
Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells
Mitochondrial transcription factor A (TFAM) is an abundant mitochondrial protein of the HMG superfamily, with various putative… (More)
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2003
2003
Nuclear genes that encode mitochondrial proteins for DNA and RNA metabolism are clustered in the Arabidopsis genome.
The plant mitochondrial genome is complex in structure, owing to a high degree of recombination activity that subdivides the… (More)
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1995
1995
Prediction and identification of new natural substrates of the yeast mitochondrial intermediate peptidase.
Most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP… (More)
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