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mitindomide

Known as: 3a,3b,4,4a,7a,8a,8b-octahydro-4,8-ethenopyrrolo(3',4':3,4)cyclobut(1,2-f)isoindole-1,3,5,7(2H,6H)-tetrone, 4, 8-Ethenopyrrolo[3',4':3,4]cyclobut[1,2-f]isoindole-1,3,5,7(2H, 6H)tetrone, octahydro-, tricyclo(4.2.2.0(2,5))dec-9-ene-3,4,7,8-tetracarboxylic acid diimide 
A bisdioxopiperazines analog with antineoplastic activity. Mitinomide inhibits topoisomerase II and slowly promotes DNA-interstrand cross-linking… Expand
National Institutes of Health

Papers overview

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2020
2020
The cardiotoxicity caused by doxorubicin and extravasation injury caused by anthracyclines is reduced by the clinically approved… Expand
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2014
2014
Six novel high energy density compounds of N, N′-azobis-polynitrodiazoles were designed. Their optimized geometric and electronic… Expand
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2012
2012
Synthesis of 1,8-dioxo-octahydroxanthene derivatives from dimedone and aldehydes using silica-supported phosphorus pentoxide (P… Expand
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2008
2008
The extractives of Eucalyptus urophydis wood consumes more bleaching agents which seriously affect the quality of pulp and paper… Expand
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2003
2003
The bisdioxopiperazines are catalytic inhibitors of eukaryotic type II DNA topoisomerases capable of trapping these enzymes as a… Expand
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1997
1997
The antitumor drug mitindomide (NSC 284356) was shown to inhibit the decatenation activity of human and Chinese hamster ovary… Expand
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1994
1994
We studied the liposome formulation characteristics of eight new lipophilic antitumour agents that have demonstrated a broad… Expand
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1991
1987
1987
A stability indicating assay for fetindomide using reversed-phase high-performance liquid chromatography (HPLC) has been… Expand
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1986
1986
Potential prodrugs of the highly insoluble, diimide antitumor agent mitindomide (1b) were synthesized by several different… Expand
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