mitindomide

Known as: 3a,3b,4,4a,7a,8a,8b-octahydro-4,8-ethenopyrrolo(3',4':3,4)cyclobut(1,2-f)isoindole-1,3,5,7(2H,6H)-tetrone, 4, 8-Ethenopyrrolo[3',4':3,4]cyclobut[1,2-f]isoindole-1,3,5,7(2H, 6H)tetrone, octahydro-, tricyclo(4.2.2.0(2,5))dec-9-ene-3,4,7,8-tetracarboxylic acid diimide 
A bisdioxopiperazines analog with antineoplastic activity. Mitinomide inhibits topoisomerase II and slowly promotes DNA-interstrand cross-linking… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1986-2003
0119862003

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
The bisdioxopiperazines are catalytic inhibitors of eukaryotic type II DNA topoisomerases capable of trapping these enzymes as a… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
1997
1997
The antitumor drug mitindomide (NSC 284356) was shown to inhibit the decatenation activity of human and Chinese hamster ovary… (More)
  • figure 1
  • figure 3
  • figure 2
  • table 1
  • figure 4
Is this relevant?
1994
1994
We studied the liposome formulation characteristics of eight new lipophilic antitumour agents that have demonstrated a broad… (More)
Is this relevant?
1987
1987
A stability indicating assay for fetindomide using reversed-phase high-performance liquid chromatography (HPLC) has been… (More)
Is this relevant?
1986
1986
Potential prodrugs of the highly insoluble, diimide antitumor agent mitindomide (1b) were synthesized by several different… (More)
Is this relevant?