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mitindomide

Known as: 3a,3b,4,4a,7a,8a,8b-octahydro-4,8-ethenopyrrolo(3',4':3,4)cyclobut(1,2-f)isoindole-1,3,5,7(2H,6H)-tetrone, 4, 8-Ethenopyrrolo[3',4':3,4]cyclobut[1,2-f]isoindole-1,3,5,7(2H, 6H)tetrone, octahydro-, tricyclo(4.2.2.0(2,5))dec-9-ene-3,4,7,8-tetracarboxylic acid diimide 
A bisdioxopiperazines analog with antineoplastic activity. Mitinomide inhibits topoisomerase II and slowly promotes DNA-interstrand cross-linking… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Isoindoles
NCIt Antineoplastic Agent Terminology

Narrower (1)

NSC 284356

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Theoretical investigation on the structure and performance of N, N′-azobis-polynitrodiazoles
Six novel high energy density compounds of N, N′-azobis-polynitrodiazoles were designed. Their optimized geometric and electronic… 
2008
2008
Determination of Biomedicine Resource of Benzene/Ethanol Extractives of Flesh Eucalyptus Urophydis Chips by Py-GC/MS
The extractives of Eucalyptus urophydis wood consumes more bleaching agents which seriously affect the quality of pulp and paper… 
2003
2003
Probing the role of linker substituents in bisdioxopiperazine analogs for activity against wild-type and mutant human topoisomerase II alpha.
The bisdioxopiperazines are catalytic inhibitors of eukaryotic type II DNA topoisomerases capable of trapping these enzymes as a… 
1997
1997
Mitindomide is a catalytic inhibitor of DNA topoisomerase II that acts at the bisdioxopiperazine binding site.
The antitumor drug mitindomide (NSC 284356) was shown to inhibit the decatenation activity of human and Chinese hamster ovary… 
1991
1991
METHOD OF SYNTHESIS OF (-)1β-ETHYL-1α-(HYDROXYMETHYL)-1,2,3,4,6,7,12,a-OCTAHYDRO- INDOLE(2,3-A)QUINOLIZINE (VARIANTS), 1-ETHYL-1-(HYDROXYMETHYL)- 1,2,3,4,6,7-HEXAHYDRO-12H-INDOLE(2,3-A)QUINOLIZINE…
FIELD: organic chemistry. SUBSTANCE: method of synthesis of (-)1β-ethyl-1α-(hydroxymethyl)-1,2,3,4,6,7,12,12b, a-octa… 
1987
1987
Stability indicating assay for fetindomide (NSC 373965), a potential prodrug of mitindomide (NSC 284356), employing high-performance liquid chromatography.
1986
1986
Synthesis of congeners and prodrugs of the benzene maleimide photoadduct mitindomide as potential antitumor agents. 2.
Potential prodrugs of the highly insoluble, diimide antitumor agent mitindomide (1b) were synthesized by several different… 
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