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mithramycin SK

National Institutes of Health

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Broader (1)

Plicamycin
analogs & derivatives

Papers overview

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2014
2014
The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription.
2012
2012
Novel mithramycins abrogate the involvement of protein factors in the transcription of cell cycle control genes.
2010
2010
Cellular response and activation of apoptosis by mithramycin SK in p21(WAF1)-deficient HCT116 human colon carcinoma cells.
2008
2008
Mithramycin SK modulates polyploidy and cell death in colon carcinoma cells
During a normal cell cycle, polyploidy and aneuploidy can be prevented by several checkpoints, which are mainly p53 dependent… 
2007
2007
Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences
The antitumour antibiotic mithramycin A (MTA) is a DNA minor-groove binding ligand. It binds to C/G-rich tracts as a dimer that… 
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