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mithramycin SK

 
National Institutes of Health

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2 relations

Broader (1)

Plicamycin
analogs & derivatives

Papers overview

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2014
2014
The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription.
DIG-MSK (demycarosyl-3D-β-D-digitoxosyl-mithramycin SK) is a recently isolated compound of the mithramycin family of antitumor… Expand
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2012
2012
Novel mithramycins abrogate the involvement of protein factors in the transcription of cell cycle control genes.
The effects of mithramycin SK (MSK) and demycarosyl-3D-β-D-digitoxosyl-mithramycin SK (DIG-MSK; EC-8042), two novel analogs of… Expand
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2010
2010
Cellular response and activation of apoptosis by mithramycin SK in p21(WAF1)-deficient HCT116 human colon carcinoma cells.
HCT116 (p21(-/-)) human colon carcinoma cells treated with mithramycin SK (MSK), a novel analog of the antitumor antibiotic… Expand
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2008
2008
Mithramycin SK modulates polyploidy and cell death in colon carcinoma cells
During a normal cell cycle, polyploidy and aneuploidy can be prevented by several checkpoints, which are mainly p53 dependent… Expand
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2007
2007
Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences
The antitumour antibiotic mithramycin A (MTA) is a DNA minor-groove binding ligand. It binds to C/G-rich tracts as a dimer that… Expand
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