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mithramycin A

 
National Institutes of Health

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2 relations

Broader (1)

Plicamycin
analogs & derivatives

Papers overview

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2014
2014
Modulation of specificity protein 1 by mithramycin A as a novel therapeutic strategy for cervical cancer
Cervical cancer is the third most common cancer and the third leading cause of death among women. However, the standard treatment… Expand
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2014
2014
The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription.
DIG-MSK (demycarosyl-3D-β-D-digitoxosyl-mithramycin SK) is a recently isolated compound of the mithramycin family of antitumor… Expand
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2013
2013
Myeloid cell leukemia-1 is a key molecular target for mithramycin A-induced apoptosis in androgen-independent prostate cancer cells and a tumor xenograft animal model.
Mithramycin A (Mith) is a natural polyketide that has been used in multiple areas of research including apoptosis of various… Expand
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2013
2013
Mithramycin A Inhibits Myeloid Cell Leukemia-1 to Induce Apoptosis in Oral Squamous Cell Carcinomas and Tumor Xenograft through Activation of Bax and Oligomerization
In several human malignancies, overexpression of myeloid cell leukemia-1 (Mcl-1) confers resistance to induction of apoptosis… Expand
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Highly Cited
2013
Highly Cited
2013
Inhibition of the transcription factor Sp1 suppresses colon cancer stem cell growth and induces apoptosis in vitro and in nude mouse xenografts.
The transcription factor specificity protein 1 (Sp1) plays a role in the development and progression of various types of human… Expand
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Highly Cited
2011
Highly Cited
2011
Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis.
Both betulinic acid (BA) and mithramycin A (MIT) exhibit potent antitumor activity through distinct mechanisms of Sp1 inhibition… Expand
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2010
2010
Therapeutic effects of the Sp1 inhibitor mithramycin A in glioblastoma
Mithramycin A (MitA) is a chemotherapeutic compound which has been used in the therapy of several types of cancer. For… Expand
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2010
2010
Differential inhibition of restriction enzyme cleavage by chromophore-modified analogues of the antitumour antibiotics mithramycin and chromomycin reveals structure-activity relationships.
Differential cleavage at three restriction enzyme sites was used to determine the specific binding to DNA of the antitumour… Expand
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Highly Cited
2007
Highly Cited
2007
Therapeutic inhibition of Sp1 expression in growing tumors by mithramycin a correlates directly with potent antiangiogenic effects on human pancreatic cancer
Human pancreatic cancer over expresses the transcription factor Sp1. However, the role of Sp1 in pancreatic cancer angiogenesis… Expand
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2007
2007
Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences
The antitumour antibiotic mithramycin A (MTA) is a DNA minor-groove binding ligand. It binds to C/G-rich tracts as a dimer that… Expand
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