mithramycin A
National Institutes of Health
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After spinal cord injury (SCI), blood-spinal cord barrier (BSCB) disruption and progressive hemorrhage lead to secondary injury…
Cervical cancer is the third most common cancer and the third leading cause of death among women. However, the standard treatment…
In several human malignancies, overexpression of myeloid cell leukemia-1 (Mcl-1) confers resistance to induction of apoptosis…
The transcription factor specificity protein 1 (Sp1) plays a role in the development and progression of various types of human…
Both betulinic acid (BA) and mithramycin A (MIT) exhibit potent antitumor activity through distinct mechanisms of Sp1 inhibition…
Mithramycin A (MitA) is a chemotherapeutic compound which has been used in the therapy of several types of cancer. For…
Human pancreatic cancer over expresses the transcription factor Sp1. However, the role of Sp1 in pancreatic cancer angiogenesis…
The antitumour antibiotic mithramycin A (MTA) is a DNA minor-groove binding ligand. It binds to C/G-rich tracts as a dimer that…