mithramycin A

 
National Institutes of Health

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Plicamycin
analogs & derivatives

Papers overview

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2014
2014
Modulation of specificity protein 1 by mithramycin A as a novel therapeutic strategy for cervical cancer
Cervical cancer is the third most common cancer and the third leading cause of death among women. However, the standard treatment… (More)
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2014
2014
The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription.
DIG-MSK (demycarosyl-3D-β-D-digitoxosyl-mithramycin SK) is a recently isolated compound of the mithramycin family of antitumor… (More)
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2013
2013
Mithramycin A induces apoptosis by regulating the mTOR/Mcl-1/tBid pathway in androgen-independent prostate cancer cells
Mithramycin A (Mith) is an aureolic acid-type polyketide produced by various soil bacteria of the genus Streptomyces. Mith… (More)
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2013
2013
Mithramycin A inhibits myeloid cell leukemia-1 to induce apoptosis in oral squamous cell carcinomas and tumor xenograft through activation of Bax and oligomerization.
In several human malignancies, overexpression of myeloid cell leukemia-1 (Mcl-1) confers resistance to induction of apoptosis… (More)
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2013
2013
Myeloid cell leukemia-1 is a key molecular target for mithramycin A-induced apoptosis in androgen-independent prostate cancer cells and a tumor xenograft animal model.
Mithramycin A (Mith) is a natural polyketide that has been used in multiple areas of research including apoptosis of various… (More)
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2011
2011
Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis.
Both betulinic acid (BA) and mithramycin A (MIT) exhibit potent antitumor activity through distinct mechanisms of Sp1 inhibition… (More)
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2010
2010
Therapeutic effects of the Sp1 inhibitor mithramycin A in glioblastoma
Mithramycin A (MitA) is a chemotherapeutic compound which has been used in the therapy of several types of cancer. For… (More)
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2010
2010
Cellular response and activation of apoptosis by mithramycin SK in p21(WAF1)-deficient HCT116 human colon carcinoma cells.
HCT116 (p21(-/-)) human colon carcinoma cells treated with mithramycin SK (MSK), a novel analog of the antitumor antibiotic… (More)
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2007
2007
Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences
The antitumour antibiotic mithramycin A (MTA) is a DNA minor-groove binding ligand. It binds to C/G-rich tracts as a dimer that… (More)
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2007
2007
Therapeutic inhibition of Sp1 expression in growing tumors by mithramycin a correlates directly with potent antiangiogenic effects on human pancreatic cancer.
BACKGROUND Human pancreatic cancer over expresses the transcription factor Sp1. However, the role of Sp1 in pancreatic cancer… (More)
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