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miltefosine

Known as: hexadecyl 2-(trimethylazaniumyl)ethyl phosphate, n-hexadecylphosphorylcholine, Choline Phosphate Hexadecyl Ester, Hydroxide, Inner Salt 
An orally- and topically-active alkyl-phosphocholine compound with potential antineoplastic activity. Miltefosine targets cellular membranes… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Lesihmaniasis is one of the major neglected tropical disease caused by the parasite of the genus Leishmania. The disease has more… Expand
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Review
2007
Review
2007
Visceral leishmaniasis (VL) is a systemic protozoan disease that is transmitted by phlebotomine sandflies. Poor and neglected… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Visceral leishmaniasis (VL) is a major public health problem in Bihar, accounting for 90% of all cases in India… Expand
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Review
2005
Review
2005
Governed by parasite and host factors and immunoinflammatory responses, the clinical spectrum of leishmaniasis encompasses… Expand
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Highly Cited
2004
Highly Cited
2004
The oral agent miltefosine has demonstrated a >95% cure rate in Indian visceral leishmaniasis. We performed a large, placebo… Expand
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Highly Cited
2004
Highly Cited
2004
ABSTRACT Miltefosine (hexadecylphosphocholine [HePC]) has proved to be a potent oral treatment for human visceral leishmaniasis… Expand
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Highly Cited
2004
Highly Cited
2004
  • N. Verma, C. Dey
  • Antimicrobial Agents and Chemotherapy
  • 2004
  • Corpus ID: 6289079
ABSTRACT Miltefosine causes leishmanial death, but the possible mechanism(s) of action is not known. The mode of action of… Expand
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Highly Cited
2003
Highly Cited
2003
The antitumor drug miltefosine (hexadecylphosphocholine, MIL) has recently been approved as the first oral agent for the… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND There are 500,000 cases per year of visceral leishmaniasis, which occurs primarily in the Indian subcontinent. Almost… Expand
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Highly Cited
1999
Highly Cited
1999
BACKGROUND There is no effective orally administered medication for any leishmania infection. We investigated miltefosine, which… Expand
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