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milameline

Known as: 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxaldehyde O-methyloxime monohydrochloride 
 
National Institutes of Health

Papers overview

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2006
2006
Abstract  RU 35926/CI‐979 (milameline) is a partial muscarinic agonist with promnestic effects in animal models. Preliminary… Expand
2006
2006
Alzheimer’s disease (AD) is a neurodegenerative disorder clinically characterized by a progressive loss of cognitive functions… Expand
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Highly Cited
2005
Highly Cited
2005
Prepulse inhibition (PPI) of the acoustic startle reflex is a sensorimotor gating process known to be deficient in a number of… Expand
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Highly Cited
2003
Highly Cited
2003
Objective: To assess the feasibility of using MRI measurements as a surrogate endpoint for disease progression in a therapeutic… Expand
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Highly Cited
2000
Highly Cited
2000
OBJECTIVE: To test the interrater reliability of the Clinical Dementia Rating (CDR) in a multicenter clinical trial. 
Highly Cited
1999
Highly Cited
1999
The purpose of our studies was to determine the effects of muscarinic receptor agonists on conditioned avoidance responding in… Expand
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1999
1999
Research into and development of selective muscarinic receptor agonists for the treatment of Alzheimer’s disease is based on the… Expand
1999
1999
Abstract  Rationale: Cholinomimetic therapy in Alzheimer’s disease (AD) has been hampered by narrow efficacious dose ranges and… Expand
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Highly Cited
1999
Highly Cited
1999
This study describes the pharmacological comparison of the muscarinic partial agonists sabcomeline, xanomeline and milameline at… Expand
Highly Cited
1998
Highly Cited
1998
Activation of muscarinic m1 receptors which are coupled to the phosphoinositide (PI) second messenger transduction system is the… Expand