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megakaryocyte development

Known as: megakaryocyte cell development 
The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte… 
National Institutes of Health

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Related topics

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Broader (1)

Megakaryocyte Differentiation

Papers overview

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Highly Cited
2014
Highly Cited
2014
Megakaryocytes Contribute to the Bone Marrow‐Matrix Environment by Expressing Fibronectin, Type IV Collagen, and Laminin
Megakaryocytes associate with the bone marrow vasculature where they convert their cytoplasm into proplatelets that protrude… 
Highly Cited
2013
Highly Cited
2013
Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function.
The SH2 domain-containing protein-tyrosine phosphatases Shp1 and Shp2 have been implicated in regulating signaling from a variety… 
Highly Cited
2007
Highly Cited
2007
HOXA10 is a critical regulator for hematopoietic stem cells and erythroid/megakaryocyte development.
The Homeobox (Hox) transcription factors are important regulators of normal and malignant hematopoiesis because they control… 
Review
2002
Review
2002
Thrombopoietin: a pan-hematopoietic cytokine.
Highly Cited
2000
Highly Cited
2000
Human mesenchymal stem cells support megakaryocyte and pro‐platelet formation from CD34+ hematopoietic progenitor cells
Megakaryocytopoiesis and thrombocytopoiesis result from the interactions between hematopoietic progenitor cells, humoral factors… 
Highly Cited
1999
Highly Cited
1999
Primary Megakaryocytes Reveal a Role for Transcription Factor Nf-E2 in Integrin αiibβ3 Signaling
Platelet integrin αIIbβ3 responds to intracellular signals by binding fibrinogen and triggering cytoskeletal reorganization, but… 
Review
1998
Review
1998
Transcription factor GATA‐1 in megakaryocyte development
The transcription factor GATA‐1 is specifically expressed in hematopoietic lineages. Prior gene knockout experiments established… 
Highly Cited
1995
Highly Cited
1995
Cloning and Characterization of the Human Megakaryocyte Growth and Development Factor (MGDF) Gene (*)
The megakaryocyte growth and development factor (MGDF) is a cytokine that regulates megakaryocyte development and is a ligand for… 
Review
1993
Review
1993
Regulation of megakaryocytopoiesis
Megakaryocytopoiesis is the cellular developmental process prior to the release of platelets into the circulation. Regulation of… 
Highly Cited
1991
Highly Cited
1991
Effects of human interleukin-6 on megakaryocyte development and thrombocytopoiesis in primates.
Recombinant human interleukin-6 (IL-6) has previously been shown to increase platelet counts in mice and primates. To elucidate… 
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