maytansinol
National Institutes of Health
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During impurity analysis of maytansinol (2), produced from the reduction of ansamitocin P‐3 (AP‐3, 1), a surprisingly stable…
The present invention, compounds of general formula 1, relates SIRT-1 activator derivatives thereof or pharmaceutically…
La presente invention a pour objet des intermediaires linker-medicament de Formule I qui sont conjugues a des anticorps pour…
A compound selected from Formula I: ** ** Formula wherein: L is: ** ** Formula E Formula ** ** is n is 2, 3, 4, 5 or 6; m is 2, 3…
A process for preparing maytansinol comprising: a) reducing a C3-ester of maytansinol with a reducing hydride reagent with…
The present invention, the processing steps were minimized, to reduce the dose of the solvent, by a method for a more efficient…
Methods of preparing maytansinol from disulfide-containing maytansinoid esters by reduction with LiAlH The maytansinol is useful…
Maytansinol (1) is the common precursor of maytansinoids (2), which are the 3-0-acyl derivatives of 1 and generally show…
Several semisynthetic maytansinoids that differ in the structure of the acyl group at the C3 position were prepared by acylation…
Bacteria, actinomycetes, yeasts, and fungi were screened for their ability to modify the structure of ansamitocins, a group of…