maytansinol
National Institutes of Health
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Trastuzumab is the first humanized monoclonal antibody targeted against the human epidermal growth factor receptor 2 (HER2…
During impurity analysis of maytansinol (2), produced from the reduction of ansamitocin P‐3 (AP‐3, 1), a surprisingly stable…
La presente invention a pour objet des intermediaires linker-medicament de Formule I qui sont conjugues a des anticorps pour…
A process for preparing maytansinol comprising: a) reducing a C3-ester of maytansinol with a reducing hydride reagent with…
Methods of preparing maytansinol from disulfide-containing maytansinoid esters by reduction with LiAlH The maytansinol is useful…
In an effort to determine the structural requirements for the significant antileukemic, cytotoxic, antitubulin, and antimitotic…
A total synthesis of maytansinol (1) was achieved, in a convergent way, using (3S,6S,7S)-aldehyde 4 and (S)-p-tolyl sulfoxide 3…
Maytansinol (1) is the common precursor of maytansinoids (2), which are the 3-0-acyl derivatives of 1 and generally show…
Several semisynthetic maytansinoids that differ in the structure of the acyl group at the C3 position were prepared by acylation…
Bacteria, actinomycetes, yeasts, and fungi were screened for their ability to modify the structure of ansamitocins, a group of…