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matriptase

Known as: EC 3.4.21.109, ST14, Suppressor of Tumorigenicity 14 
Suppressor of tumorigenicity 14 protein (855 aa, ~95 kDa) is encoded by the human ST14 gene. This protein is involved in proteolysis of extracellular… 
National Institutes of Health

Related topics

Related topics

22 relations
Colon structure (body structure)Enzyme GeneHomo sapiensHydrolysis

Broader (1)

Serine Endopeptidases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Design and synthesis of novel and potent inhibitors of the type II transmembrane serine protease, matriptase, based upon the sunflower trypsin inhibitor-1.
Matriptase, initially isolated from human breast cancer cells in culture, is a member of the emerging class of type II… 
Highly Cited
2007
Highly Cited
2007
The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1).
Highly Cited
2006
Highly Cited
2006
Delineation of matriptase protein expression by enzymatic gene trapping suggests diverging roles in barrier function, hair formation, and squamous cell carcinogenesis.
The membrane serine protease matriptase is required for epidermal barrier function, hair formation, and thymocyte development in… 
Highly Cited
2005
Highly Cited
2005
In vitro inhibition of matriptase prevents invasive growth of cell lines of prostate and colon carcinoma.
Matriptase, also known as membrane-type-serine-protease 1 (MT-SP 1), is a type II transmembrane serine protease involved in the… 
2005
2005
Production of soluble matriptase by human cancer cell lines and cell surface activation of its zymogen by trypsin
The membrane‐bound serine proteinase matriptase, which is often released from the plasma membrane of epithelial and carcinoma… 
Highly Cited
2001
Highly Cited
2001
Structure-based approach for the discovery of bis-benzamidines as novel inhibitors of matriptase.
Matriptase, a trypsin-like serine protease, which may be involved in tissue remodeling, cancer invasion, and metastasis. Potent… 
Highly Cited
1999
Highly Cited
1999
Cloning and chromosomal mapping of a gene isolated from thymic stromal cells encoding a new mouse type II membrane serine protease, epithin, containing four LDL receptor modules and two CUB domains
Abstract We cloned and sequenced a mouse gene encoding a new type of membrane bound serine protease (epithin) containing a… 
1989
1989
Toward a physical map of the Xq28 region in man: linking color vision, G6PD, and coagulation factor VIII genes to an X-Y homology region.
1987
1987
Linkage and genetic counselling for the fragile X using DNA probes 52A, F9, DX13, and ST14.
Linkage data using the markers DXS51, F9, DXS15, and DXS52 are presented from 14 pedigrees segregating with the fragile X… 
1987
1987
Mapping of DNA markers close to the fragile site on the human X chromosome at Xq27.3.
We report the identification of a new RFLP detected by the DNA probe MN12, which is linked to both the fragile site on the X… 
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