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malagashanine

National Institutes of Health

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Alkaloids

Papers overview

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2011
2011
Towards a Total Synthesis of Malagashanine - a Structurally Unique Strychnos Alkaloid with the Potential to Impact both Malaria and Cancer Chemotherapy
Malagashanine was isolated from the Madagascan shrub Strychnos Myrtoides, and it’s structure was assigned in 1994. It was found… 
2010
2010
Glutathione transferase from Plasmodium falciparum – Interaction with malagashanine and selected plant natural products
A glutathione transferase (PfGST) isolated from Plasmodium falciparum has been associated with chloroquine resistance. A range of… 
2010
2010
Development of a Novel Cascade Cyclization Reaction and its Application Towards the Total Synthesis of Malagashanine: A Chloroquine Efflux Inhibitor
Development of a Novel Cascade Cyclization Reaction and its Application Towards the Total Synthesis of Malagashanine: A… 
2006
2006
Malagashanine potentiates chloroquine antimalarial activity in drug resistant Plasmodium malaria by modifying both its efflux and influx.
2001
2001
Biological activities of the plant‐derived bisindole voacamine with reference to malaria
The in vivo antiplasmodial activity of voacamine was assessed in a 4‐day test. It was shown to exhibit in vivo activity with 25.4… 
2000
2000
Reversal activity of the naturally occurring chemosensitizer malagashanine in Plasmodium malaria.
2000
2000
Isolation from rat urine and human liver microsomes and identification by electrospray and nanospray tandem mass spectrometry of new malagashanine metabolites.
Malagashanine has been isolated from indigenous madagascan Strychnos myrtoides alkaloids used traditionally to treat malaria… 
2000
2000
High-performance liquid chromatographic assay of malagashanine in rat plasma and urine and its pharmacokinetic application.
Review
1996
Review
1996
[Recent results on the pharmacodynamics of Strychnos malgaches alkaloids].
Investigation of Strychnos (Loganiaceae) shrubs and trees was initiated by their traditional uses of their inherent poisons on… 
Highly Cited
1994
Highly Cited
1994
In vitro and in vivo chloroquine-potentiating action of Strychnos myrtoides alkaloids against chloroquine-resistant strains of Plasmodium malaria.
Crude alkaloids of Strychnos myrtoides Gilg & Busse, empirically used as an adjuvant to chloroquine (CQ) in Malagasy herbal… 
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