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malagashanine

 
National Institutes of Health

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Alkaloids

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2016
2016
malagashanine : a chloroquine potentiating indole alkaloid with unusual stereochemistry †
Malagashanine (1, Fig. 1) is a structurally unusual alkaloid that was isolated from the stem bark of the Madagascan shrub… Expand
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2011
2011
Towards a Total Synthesis of Malagashanine - a Structurally Unique Strychnos Alkaloid with the Potential to Impact both Malaria and Cancer Chemotherapy
Malagashanine was isolated from the Madagascan shrub Strychnos Myrtoides, and it’s structure was assigned in 1994. It was found… Expand
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2010
2010
Development of a Novel Cascade Cyclization Reaction and its Application Towards the Total Synthesis of Malagashanine: A Chloroquine Efflux Inhibitor
Development of a Novel Cascade Cyclization Reaction and its Application Towards the Total Synthesis of Malagashanine: A… Expand
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2010
2010
Glutathione transferase from Plasmodium falciparum--interaction with malagashanine and selected plant natural products.
A glutathione transferase (PfGST) isolated from Plasmodium falciparum has been associated with chloroquine resistance. A range of… Expand
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2006
2006
Malagashanine potentiates chloroquine antimalarial activity in drug resistant Plasmodium malaria by modifying both its efflux and influx.
Malagashanine (MG) is the parent compound of the new N(b)-C(21) seco-curan alkaloids isolated hitherto from Madagascan Strychnos… Expand
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2001
2001
Biological activities of the plant-derived bisindole voacamine with reference to malaria.
The in vivo antiplasmodial activity of voacamine was assessed in a 4-day test. It was shown to exhibit in vivo activity with 25.4… Expand
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2000
2000
Reversal activity of the naturally occurring chemosensitizer malagashanine in Plasmodium malaria.
Malagashanine (MG) is the parent compound of a new type of indole alkaloids, the N(b)C(21)-secocuran, isolated so far from the… Expand
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2000
2000
High-performance liquid chromatographic assay of malagashanine in rat plasma and urine and its pharmacokinetic application.
A reversed-phase HPLC method was developed for quantitative analysis of malagashanine in rat plasma and urine. Malagashanine and… Expand
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2000
2000
Isolation from rat urine and human liver microsomes and identification by electrospray and nanospray tandem mass spectrometry of new malagashanine metabolites.
Malagashanine has been isolated from indigenous madagascan Strychnos myrtoides alkaloids used traditionally to treat malaria… Expand
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1994
1994
In vitro and in vivo chloroquine-potentiating action of Strychnos myrtoides alkaloids against chloroquine-resistant strains of Plasmodium malaria.
Crude alkaloids of Strychnos myrtoides Gilg & Busse, empirically used as an adjuvant to chloroquine (CQ) in Malagasy herbal… Expand
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