• Publications
  • Influence
Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction
  • R. Verbeeck
  • Medicine, Biology
    European Journal of Clinical Pharmacology
  • 2008
TLDR
Patients with advanced cirrhosis often have impaired renal function and dose adjustment may, therefore, also be necessary for drugs eliminated by renal exctretion, and further research is needed to develop more sensitive liver function tests to guide drug dosage adjustment in patients with hepatic dysfunction.
Pharmacokinetics and dosage adjustment in patients with renal dysfunction
TLDR
It is shown that renal dysfunction affects more that just the renal handling of drugs and/or active drug metabolites, and a re-evaluation of markers of renal function may be required, even when the dosage adjustment recommended for patients with renal dysfunction are carefully followed.
Comparative Clinical Pharmacokinetics of Tacrolimus in Paediatric and Adult Patients
TLDR
The rate and extent of tacrolimus absorption after oral administration do not seem to be altered in paediatric patients, but oral doses need to be generally 2-fold higher than corresponding adult doses to reach similar tacolimus blood concentrations.
Systemic delivery of parathyroid hormone (1-34) using inhalation dry powders in rats.
TLDR
Equilibrium dialysis revealed a 78% binding of PTH to albumin and the withdrawal of albumin from the powder increased absolute bioavailability after inhalation, which makes it a promising alternative to subcutaneous injection.
Role of taurine in osmoregulation during endurance exercise
TLDR
Investigating whether the exercise-stimulated release of taurine from muscle into the plasma regulates the modification of osmolality induced by intramuscular osmolyte production concluded that changes in the plasma t aurine content during endurance exercise is related to an osmoregulatory process, but this alone does not control plasma volume changes.
Differential activities of CYP1A isozymes in hepatic and intestinal microsomes of control and 3-methylcholanthrene-induced rats.
TLDR
Different expression and inducibility of CYP1A1/1A2 by 3-methylcholanthrene in rat liver and small intestine shows different changes in the contribution of the various isoenzymes involved in the biotransformation of caffeine.
Clinical Pharmacokinetics of Non-steroidal Anti-inflammatory Drugs
TLDR
The most important interactions with NSAIDs are those involving the oral anticoagulants and oral hypoglycaemic agents, though not all NSAIDs have been found to interact with these drugs.
Binding of phenothiazine neuroleptics to plasma proteins.
Effect of hepatic insufficiency on pharmacokinetics and drug dosing
TLDR
D dosage reduction is necessary for many drugs administered to patients with chronic liver disease such as liver cirrhosis, because of reduced liver blood flow and the systemic clearance of flow limited drugs and portal‐systemic shunting.
Differential induction of midazolam metabolism in the small intestine and liver by oral and intravenous dexamethasone pretreatment in rat
TLDR
Induction by oral or intravenous dexamethasone pretreatment led to significant increases in Vmax for 4-OH- MDZ and 1'-OH-MDZ by both intestinal and hepatic microsomes, suggesting that intestinal CYP3A enzymes in the rat differ from hepatic CYP2A1 and CYP4A2.
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