magnesium chelatase activity

Known as: Mg-protoporphyrin IX chelatase activity, magnesium-chelatase activity, magnesium-protoporphyrin IX chelatase activity 
Catalysis of the reaction: ATP + H(2)O + Mg(2+) + protoporphyrin IX = ADP + 2 H(+) + magnesium protoporphyrin IX + phosphate. [EC:6.6.1.1, RHEA:13964… (More)
National Institutes of Health

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Highly Cited
2006
Highly Cited
2006
Hemin activation ameliorates HIV-1 infection via heme oxygenase-1 induction.
Hemin, a critical component of hemoglobin, is an active ingredient of a biologic therapeutic approved by the Food and Drug… (More)
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Highly Cited
2005
Highly Cited
2005
Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury.
Ischemia/reperfusion injury (IRI) represents the major problem in clinical liver transplantation. We have shown that toll-like… (More)
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Highly Cited
2004
Highly Cited
2004
Probucol protects against smooth muscle cell proliferation by upregulating heme oxygenase-1.
BACKGROUND Evidence suggests that induction of heme oxygenase-1 (HO-1) inhibits proliferation of vascular smooth muscle cells and… (More)
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Highly Cited
2003
Highly Cited
2003
Inhibition of lipopolysaccharide-induced nitric oxide production by flavonoids in RAW264.7 macrophages involves heme oxygenase-1.
The role of heme oxygenase-1 (HO-1) played in the inhibitory mechanism of flavonoids in lipopolysaccharide (LPS)-induced… (More)
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Highly Cited
2003
Highly Cited
2003
Nerve growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a phosphatidylinositol 3-kinase-dependent manner.
The survival signal elicited by the phosphatidylinositol 3-kinase (PI3K)/Akt1 pathway has been correlated with inactivation of… (More)
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Highly Cited
2001
Highly Cited
2001
Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants.
Mouse-to-rat cardiac transplants survive long term after transient complement depletion by cobra venom factor and T cell… (More)
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Highly Cited
2000
Highly Cited
2000
Role of magnesium chelatase activity in the early steps of the tetrapyrrole biosynthetic pathway.
Magnesium-protoporphyrin IX chelatase (Mg-chelatase) is located at the branchpoint of tetrapyrrole biosynthesis, at which point… (More)
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Highly Cited
2000
Highly Cited
2000
Heme oxygenase-1 inhibits TNF-alpha-induced apoptosis in cultured fibroblasts.
Heme oxygenase (HO)-1 catalyzes the oxidative cleavage of heme to yield equimolar amounts of biliverdin, iron, and carbon… (More)
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1996
1996
Three separate proteins constitute the magnesium chelatase of Rhodobacter sphaeroides.
The insertion of magnesium into protoporphyrin IX is the first step unique to chlorophyll production and is catalyzed by… (More)
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Highly Cited
1995
Highly Cited
1995
Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP.
Carbon monoxide (CO) is a product of the enzyme heme oxygenase (HO; EC 1.14.99.3). In vascular smooth muscle cells, exogenously… (More)
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