mTOR Inhibitor

Any substance that inhibits mammalian target of rapamycin (mTOR or FK506 binding protein 12-rapamycin associated protein 1 (FRAP1)), a serine… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1999-2017
010020019992017

Papers overview

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Review
2017
Review
2017
Deptor is an important protein that belongs to the mTORC1 and mTORC2 complexes, able to interact with mTOR and to inhibit its… (More)
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Highly Cited
2009
Highly Cited
2009
The mTORC1 and mTORC2 pathways regulate cell growth, proliferation, and survival. We identify DEPTOR as an mTOR-interacting… (More)
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Highly Cited
2008
Highly Cited
2008
Phosphatidylinositol-3-kinase (PI3K) pathway deregulation is a common event in human cancer, either through inactivation of the… (More)
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Highly Cited
2006
Highly Cited
2006
The PI3 kinase family of lipid kinases promotes cell growth and survival by generating the second messenger phosphatidylinositol… (More)
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Highly Cited
2005
Highly Cited
2005
Although DNA damaging agents have revolutionized chemotherapy against solid tumors, a narrow therapeutic window combined with… (More)
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Highly Cited
2004
Highly Cited
2004
Huntington disease is one of nine inherited neurodegenerative disorders caused by a polyglutamine tract expansion. Expanded… (More)
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Highly Cited
2004
Highly Cited
2004
Evading apoptosis is considered to be a hallmark of cancer, because mutations in apoptotic regulators invariably accompany… (More)
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Highly Cited
2002
Highly Cited
2002
In multicellular organisms, constituent cells depend on extracellular signals for growth, proliferation, and survival. When cells… (More)
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Highly Cited
2001
Highly Cited
2001
The mammalian target of rapamycin (mTOR) is a central regulator of G1 cell cycle protein synthesis that precedes commitment to… (More)
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Highly Cited
2000
Highly Cited
2000
Neuropoletic cytokines such as ciliary neurotrophic factor (CNTF) can activate multiple signaling pathways in parallel, including… (More)
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