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mRNA Degradation

Known as: mRNA catabolic process, mRNA catabolism, Degradation, mRNA 
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message… 
National Institutes of Health

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mRNA Decaynegative regulation of mRNA catabolic process

Papers overview

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Highly Cited
2014
Highly Cited
2014
A post-translational regulatory switch on UPF1 controls targeted mRNA degradation
Nonsense-mediated mRNA decay (NMD) controls the quality of eukaryotic gene expression and also degrades physiologic mRNAs. Here… 
Review
2011
Review
2011
Roles of Puf proteins in mRNA degradation and translation
Puf proteins are regulators of diverse eukaryotic processes including stem cell maintenance, organelle biogenesis, oogenesis… 
Review
2008
Review
2008
ZAP-mediated mRNA degradation
The zinc-finger antiviral protein (ZAP) is a host factor that inhibits the replication of many viruses by preventing the… 
Highly Cited
2005
Highly Cited
2005
The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans.
Highly Cited
2003
Highly Cited
2003
The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies.
A novel cytoplasmic compartment referred to as GW bodies (GWBs) was initially identified using antibodies specific to a 182-kD… 
Highly Cited
1999
Highly Cited
1999
Induction of Interleukin-8 Synthesis Integrates Effects on Transcription and mRNA Degradation from at Least Three Different Cytokine- or Stress-Activated Signal Transduction Pathways
ABSTRACT A hallmark of inflammation is the burst-like formation of certain proteins, initiated by cellular stress and… 
Highly Cited
1998
Highly Cited
1998
Double-stranded RNA induces mRNA degradation in Trypanosoma brucei.
Double-stranded RNA (dsRNA) recently has been shown to give rise to genetic interference in Caenorhabditis elegans and also is… 
Highly Cited
1996
Highly Cited
1996
AUF1 Binding Affinity to A+U-rich Elements Correlates with Rapid mRNA Degradation (*)
Rapid degradation of many labile mRNAs is regulated in part by an A+U-rich element (ARE) in their 3′-untranslated regions… 
Highly Cited
1988
Highly Cited
1988
Premature translation termination mediates triosephosphate isomerase mRNA degradation
We characterized an anemia-inducing mutation in the human gene for triosephosphate isomerase (TPI) that resulted in the… 
Highly Cited
1983
Highly Cited
1983
Histone mRNA concentrations are regulated at the level of transcription and mRNA degradation.
The levels of histone mRNA are rapidly reduced after treatment of cultured cells with hydroxyurea or cytosine arabinonucleoside… 
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