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Stress granules and processing bodies are dynamically linked sites of mRNP remodeling
It is proposed that mRNA released from disassembled polysomes is sorted and remodeled at SGs, from which selected transcripts are delivered to PBs for degradation, an interaction that is promoted by the related mRNA decay factors TTP and BRF1.
Disruption of GW bodies impairs mammalian RNA interference
It is demonstrated that endogenous Ago2 and transfected small interfering RNAs (siRNAs) are also present within these same cytoplasmic bodies and that the GW182 protein interacts with Ago2.
A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles.
- T. Eystathioy, E. K. Chan, S. Tenenbaum, J. Keene, K. Griffith, M. Fritzler
- BiologyMolecular biology of the cell
- 1 April 2002
It is proposed that the GW ribonucleoprotein complex is involved in the posttranscriptional regulation of gene expression by sequestering a specific subset of gene transcripts involved in cell growth and homeostasis.
Autoantibodies and microvascular damage are independent predictive factors for the progression of Raynaud's phenomenon to systemic sclerosis: a twenty-year prospective study of 586 patients, with…
In RP evolving to definite SSc, microvascular damage is dynamic and sequential, while SSc-specific autoantibodies are associated with the course and type of capillary abnormalities.
Range of antinuclear antibodies in "healthy" individuals.
It is recommended that laboratories performing immunofluorescent ANA tests should report results at both the 1:40 and 1:160 dilutions, and should supply information on the percentage of normal individuals who are positive at these dilutions.
International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies
- N. Agmon-Levin, J. Damoiseaux, Y. Shoenfeld
- Medicine, BiologyAnnals of the rheumatic diseases
- 14 October 2013
Recommendations for the assessment and interpretation of ANA and associated antibodies were formulated and the roles of IIFA as a reference method, and the importance of defining nuclear and cytoplasmic staining were emphasised, while the need to incorporate alternative automated methods was acknowledged.
The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies.
It is demonstrated that GW182, hLSm4, and hDcp1 are found in the same cytoplasmic structures and suggested that GW 182 is involved in the the same mRNA processing pathway as h LSm4 and h Dcp1.
Mycophenolate Mofetil versus Oral Cyclophosphamide in Scleroderma-related Interstitial Lung Disease: Scleroderma Lung Study II (SLS-II), a double-blind, parallel group, randomised controlled trial
GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation
The incremental expression of the GW182 protein in cells induced to proliferate and the cyclic formation and breakdown of GW bodies during mitosis are intriguing in view of the notion that GW bodies are specialized centers involved in maintaining stability and/or controlling degradation of mRNA.