lubiprostone

Known as: 7-((1R,4R,6R,9R)-4-(1,1-difluoropentyl)-4-hydroxy-8-oxo-5-oxabicyclo(4.3.0)non-9-yl)heptanoic acid, Lubiprostone [Chemical/Ingredient], Prostan-1-oic acid, 16,16-difluoro-11-hydroxy-9,15-dioxo-, (11alpha)- 
A bicyclic fatty acid derived from prostaglandin E1 and a chloride channel activator with laxative activity. Upon intake, lubiprostone specifically… (More)

Topic mentions per year

Topic mentions per year

2004-2018
010203020042018

Papers overview

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2012
2012
Lubiprostone is a chloride channel activator in clinical use for the treatment of chronic constipation, but the mechanisms of… (More)
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2009
2009
Lubiprostone, a bicyclic fatty acid, is used for the treatment of chronic constipation. No published study has addressed the… (More)
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2009
2009
BACKGROUND & AIMS Lubiprostone alleviates constipation by stimulating intestinal fluid secretion, purportedly through activation… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Effective treatments for irritable bowel syndrome with constipation (IBS-C) are lacking. AIM To assess the efficacy… (More)
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2009
2009
The aim of this study is to assess the efficacy and safety of lubiprostone in adults with chronic constipation. This multicenter… (More)
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2009
2009
Lubiprostone, a bicyclic fatty acid chloride channel activator, is efficacious in treatment of chronic constipation and… (More)
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2008
2008
BACKGROUND Analyses of a trial in constipated patients indicated that lubiprostone may be an effective treatment for irritable… (More)
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2008
2008
OBJECTIVES:To assess the efficacy and safety of lubiprostone in adults with chronic constipation.METHODS:This multicenter… (More)
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2007
2007
BACKGROUND Lubiprostone, a locally acting type-2 chloride channel activator, induces intestinal fluid secretion. AIM To assess… (More)
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Highly Cited
2006
Highly Cited
2006
Chloride channels modulate gastrointestinal neuromuscular functions in vitro. Lubiprostone, a selective type 2 chloride channel… (More)
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