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lubiprostone

Known as: 7-((1R,4R,6R,9R)-4-(1,1-difluoropentyl)-4-hydroxy-8-oxo-5-oxabicyclo(4.3.0)non-9-yl)heptanoic acid, Lubiprostone [Chemical/Ingredient], Prostan-1-oic acid, 16,16-difluoro-11-hydroxy-9,15-dioxo-, (11alpha)- 
A bicyclic fatty acid derived from prostaglandin E1 and a chloride channel activator with laxative activity. Upon intake, lubiprostone specifically… Expand
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Objective To compare efficacy of pharmacotherapies for chronic idiopathic constipation (CIC) based on comparisons to placebo… Expand
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Review
2017
Review
2017
Objective To formulate timely evidence-based guidelines for the management of opioid-induced bowel dysfunction. Setting… Expand
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Highly Cited
2015
Highly Cited
2015
The accumulation of uremic toxins is involved in the progression of CKD. Various uremic toxins are derived from gut microbiota… Expand
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Highly Cited
2014
Highly Cited
2014
OBJECTIVE To evaluate the efficacy and safety of oral lubiprostone for relieving symptoms of opioid-induced constipation (OIC) in… Expand
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Effective treatments for irritable bowel syndrome with constipation (IBS-C) are lacking. AIM To assess the efficacy… Expand
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Highly Cited
2009
Highly Cited
2009
AimsThe aim of this study is to assess the efficacy and safety of lubiprostone in adults with chronic constipation.MethodsThis… Expand
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Highly Cited
2008
Highly Cited
2008
OBJECTIVES:To assess the efficacy and safety of lubiprostone in adults with chronic constipation.METHODS:This multicenter… Expand
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Analyses of a trial in constipated patients indicated that lubiprostone may be an effective treatment for irritable… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Lubiprostone, a locally acting type-2 chloride channel activator, induces intestinal fluid secretion. AIM To assess… Expand
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Highly Cited
2006
Highly Cited
2006
Chloride channels modulate gastrointestinal neuromuscular functions in vitro. Lubiprostone, a selective type 2 chloride channel… Expand
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