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lobaplatin

Known as: 1,2-diaminomethylcyclobutane-platinum(II) lactate, 1,2-diammino-methy lcyclobutane-platinum (II) lactate 
A third-generation, water-soluble platinum compound with potential antineoplastic activity. Lobaplatin forms highly reactive, charged, platinum… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
PURPOSE This phase II study was undertaken to determine the efficacy and safety of Loubo® (Lobaplatin) in combination with… Expand
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2013
2013
AIMS To explore efficacy and side effects of intrapleural or intraperitoneal lobaplatin for treating patients with malignant… Expand
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Highly Cited
2010
Highly Cited
2010
Since its approval in 1979 cisplatin has become an important component in chemotherapy regimes for the treatment of ovarian… Expand
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Review
2009
Review
2009
DNA is believed to be the primary target for many metal-based drugs. For example, platinum-based anticancer drugs can form… Expand
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Highly Cited
2005
Highly Cited
2005
The cytotoxicity of cisplatin and cisplatin-DNA adduct formation in vitro and in vivo is clearly enhanced by hyperthermia. We… Expand
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Review
2001
Review
2001
  • M. McKeage
  • Expert opinion on investigational drugs
  • 2001
  • Corpus ID: 23771556
Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexes containing a 1,2-bis(aminomethyl)cyclobutane stable… Expand
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Highly Cited
1996
Highly Cited
1996
Two interesting representatives of a new generation of platinum-based cytostatic drugs that are currently being tested in… Expand
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1996
1996
The combination of VP‐16 and cisplatin is one of the most active regimens available for the treatment of small cell lung cancer… Expand
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1995
1995
In phase I studies, lobaplatin showed activity in ovarian cancer patients pretreated with platinum. A phase II trial with… Expand
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Highly Cited
1992
Highly Cited
1992
The role of glutathione (GSH) in the effectiveness of and resistance to 7 platinum compounds [5 Pt(II) and 2 Pt(IV) drugs] was… Expand
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