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lipstatin

 
National Institutes of Health

Papers overview

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2014
2014
ABSTRACT Lipstatin, isolated from Streptomyces toxytricini as a potent and selective inhibitor of human pancreatic lipase, is a… Expand
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2010
2010
Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two… Expand
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2003
2003
The lipophilic beta-lactone, lipstatin, inhibits pancreatic lipase and has been shown earlier to be biosynthesized by Claisen… Expand
2002
2002
Three putative intermediates in the biosynthesis of the lipase inhibitor lipstatin were synthesized in stable isotope-labeled… Expand
2001
2001
Fermentation experiments with Streptomyces toxytricini were performed using (5Z,8Z)-[10,11,12,12-(2)H]tetradeca-5,8-dienoic acid… Expand
Review
1997
Review
1997
  • R. Guerciolini
  • International journal of obesity and related…
  • 1997
  • Corpus ID: 8601296
Gastric and pancreatic lipases are enzymes that play a pivotal role in the digestion of dietary fat. Orlistat, a semisynthetic… Expand
Review
1992
Review
1992
Excessive intake of dietary fat contributes to the development and maintenance of both obesity and hyperlipidemia. Inhibition of… Expand
Highly Cited
1988
Highly Cited
1988
  • B. Borgström
  • Biochimica et biophysica acta
  • 1988
  • Corpus ID: 24051271
Tetrahydrolipstatin is a specific lipase inhibitor derived from lipstatin, a lipid produced by Streptomyces toxytricini. In… Expand
Highly Cited
1987
Highly Cited
1987
Lipstatin, a new and very potent inhibitor of pancreatic lipase (the key enzyme of intestinal fat digestion) was isolated from… Expand
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Highly Cited
1987
Highly Cited
1987
The structure of a new pancreatic lipase inhibitor, lipstatin, produced by Streptomyces toxytricini was determined as (2S,3S,5S… Expand
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