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lipstatin

 
National Institutes of Health

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2010
2010
Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two… Expand
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2003
2003
The lipophilic beta-lactone, lipstatin, inhibits pancreatic lipase and has been shown earlier to be biosynthesized by Claisen… Expand
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2002
2002
Three putative intermediates in the biosynthesis of the lipase inhibitor lipstatin were synthesized in stable isotope-labeled… Expand
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2000
2000
The lipase inhibitor lipstatin is biosynthesized in Streptomyces toxytricini via condensation of a C(14) precursor and a C(8… Expand
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Review
1997
Review
1997
Gastric and pancreatic lipases are enzymes that play a pivotal role in the digestion of dietary fat. Orlistat, a semisynthetic… Expand
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1997
1997
The biosynthesis of the pancreatic lipase inhibitor lipstatin was investigated by fermentation experiments using cultures of… Expand
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Review
1992
Review
1992
Excessive intake of dietary fat contributes to the development and maintenance of both obesity and hyperlipidemia. Inhibition of… Expand
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Highly Cited
1988
Highly Cited
1988
Tetrahydrolipstatin is a specific lipase inhibitor derived from lipstatin, a lipid produced by Streptomyces toxytricini. In… Expand
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Highly Cited
1987
Highly Cited
1987
Lipstatin, a new and very potent inhibitor of pancreatic lipase (the key enzyme of intestinal fat digestion) was isolated from… Expand
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1987
1987
The structure of a new pancreatic lipase inhibitor, lipstatin, produced by Streptomyces toxytricini was determined as (2S,3S,5S… Expand
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