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lipstatin
National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
Lactones
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Operon for Biosynthesis of Lipstatin, the Beta-Lactone Inhibitor of Human Pancreatic Lipase
Tingli Bai
,
Daozhong Zhang
,
+7 authors
Meifeng Tao
Applied and Environmental Microbiology
2014
Corpus ID: 24968721
ABSTRACT Lipstatin, isolated from Streptomyces toxytricini as a potent and selective inhibitor of human pancreatic lipase, is a…
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2010
2010
Click-based synthesis and proteomic profiling of lipstatin analogues.
M. H. Ngai
,
P. Yang
,
+4 authors
M. J. Lear
Chemical communications
2010
Corpus ID: 3728767
Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two…
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2003
2003
Biosynthetic origin of a branched chain analogue of the lipase inhibitor, lipstatin.
W. Eisenreich
,
E. Kupfer
,
P. Stohler
,
W. Weber
,
A. Bacher
Journal of medicinal chemistry
2003
Corpus ID: 22990916
The lipophilic beta-lactone, lipstatin, inhibits pancreatic lipase and has been shown earlier to be biosynthesized by Claisen…
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2002
2002
Biosynthetic precursors of the lipase inhibitor lipstatin.
C. A. Schuhr
,
W. Eisenreich
,
+4 authors
A. Bacher
The Journal of organic chemistry
2002
Corpus ID: 30835502
Three putative intermediates in the biosynthesis of the lipase inhibitor lipstatin were synthesized in stable isotope-labeled…
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2001
2001
Biosynthesis of lipstatin. Incorporation of multiply deuterium-labeled (5Z,8Z)-tetradeca-5,8-dienoic acid and octanoic acid.
M. Goese
,
W. Eisenreich
,
+4 authors
A. Bacher
The Journal of organic chemistry
2001
Corpus ID: 23541697
Fermentation experiments with Streptomyces toxytricini were performed using (5Z,8Z)-[10,11,12,12-(2)H]tetradeca-5,8-dienoic acid…
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Review
1997
Review
1997
Mode of action of orlistat.
R. Guerciolini
International journal of obesity and related…
1997
Corpus ID: 8601296
Gastric and pancreatic lipases are enzymes that play a pivotal role in the digestion of dietary fat. Orlistat, a semisynthetic…
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Review
1992
Review
1992
Initial studies in humans with the novel gastrointestinal lipase inhibitor Ro 18-0647 (tetrahydrolipstatin).
J. Hauptman
,
F. Jeunet
,
D. Hartmann
The American journal of clinical nutrition
1992
Corpus ID: 39581444
Excessive intake of dietary fat contributes to the development and maintenance of both obesity and hyperlipidemia. Inhibition of…
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Highly Cited
1988
Highly Cited
1988
Mode of action of tetrahydrolipstatin: a derivative of the naturally occurring lipase inhibitor lipstatin.
B. Borgström
Biochimica et biophysica acta
1988
Corpus ID: 24051271
Tetrahydrolipstatin is a specific lipase inhibitor derived from lipstatin, a lipid produced by Streptomyces toxytricini. In…
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Highly Cited
1987
Highly Cited
1987
Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity.
E. K. Weibel
,
P. Hadváry
,
E. Hochuli
,
E. Kupfer
,
H. Lengsfeld
The Journal of antibiotics
1987
Corpus ID: 7103932
Lipstatin, a new and very potent inhibitor of pancreatic lipase (the key enzyme of intestinal fat digestion) was isolated from…
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Highly Cited
1987
Highly Cited
1987
Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. II. Chemistry and structure elucidation.
E. Hochuli
,
E. Kupfer
,
R. Maurer
,
W. Meister
,
Y. Mercadal
,
K. Schmidt
The Journal of antibiotics
1987
Corpus ID: 5182502
The structure of a new pancreatic lipase inhibitor, lipstatin, produced by Streptomyces toxytricini was determined as (2S,3S,5S…
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