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Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
The results generally agree well with the previous studies using CB1 receptor autoradiography and messenger RNA in situ hybridization, but because of its greater resolution, immunohistochemistry allowed identification of particular neuronal cells and fibers that possess cannabinoid receptors.
An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors
The hypothesis, based on previous structure-activity relationship studies and the availability of biosynthetic precursors, that N-arachidonoyl-dopamine (NADA) is an endogenous “capsaicin-like” substance in mammalian nervous tissues is examined and found that NADA occurs in nervous tissues.
An endocannabinoid mechanism for stress-induced analgesia
The results indicate that the coordinated release of 2-AG and anandamide in the periaqueductal grey matter might mediate opioid-independent stress-induced analgesia, and identify monoacylglycerol lipase as a previously unrecognized therapeutic target.
Identification of a New Class of Molecules, the Arachidonyl Amino Acids, and Characterization of One Member That Inhibits Pain*
It is shown that the conjugate of arachidonic acid and glycine (N-arachidonylglycine (NAGly) is present in bovine and rat brain as well as other tissues and that it suppresses tonic inflammatory pain.
N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor
NAGly is the most effective lipid recruiter of BV-2 microglia currently reported and its effects mimic those of Abn-CBD, and the hypothesis that GPR18 is the previously unidentified 'Abn- CBD' receptor is supported.
Endogenous opioids: biology and function.
even less so. It was therefore impossible for the functionally minded neuro­ scientist to design and execute experiments taking this heterogeneity into consideration. Even pharmacological studies
Pain modulation by release of the endogenous cannabinoid anandamide.
Findings indicate that the endogenous cannabinoid anandamide plays an important role in a cannabinergic pain-suppression system existing within the dorsal and lateral PAG, and may have relevance for the treatment of pain, particularly in instances where opiates are ineffective.
N-Oleoyldopamine, a Novel Endogenous Capsaicin-like Lipid That Produces Hyperalgesia*
N-Arachidonoyldopamine (NADA) was recently identified as an endogenous ligand for the vanilloid type 1 receptor (VR1). Further analysis of the bovine striatal extract from which NADA was isolated
Sigma receptors: biology and function.
Cannabinoid CB1 receptors are localized primarily on cholecystokinin-containing GABAergic interneurons in the rat hippocampal formation
Localization of cannabinoid CB 1 receptors on GABAergic interneurons in the rat hippocampal formation was studied by double-labeling immunohistochemistry with confocal microscopy, suggesting that cannabinoids may modulate GABAergic neurotransmission at the synapse on the soma and at synapses on the proximal dendrites of the principal neurons, as well as atsynapses on other GABAergicinterneuron.