FAQ

lipoprotein receptor-related protein 6

Known as: Low Density Lipoprotein Receptor-Related Protein 6, Low Density Lipoprotein Receptor Related Protein 6, Low Density Lipoprotein Receptor-Related Protein-6 
An LDL-receptor related protein that combines with cell surface FRIZZLED RECEPTORS to form WNT PROTEIN-binding receptors. The protein plays an… (More)
National Institutes of Health

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2003-2017
0102020032017

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In BloodLRP6 geneagonistsantagonists & inhibitors
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LRP6 protein, human

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
lipoprotein receptor-related protein 6
physiological aspects
In Blood
LRP6 protein, human
LRP6 gene
antagonists & inhibitors

Papers overview

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2016
2016
Lipoprotein receptor-related protein 6 is required for parathyroid hormone-induced Sost suppression.
Parathyroid hormone (PTH) suppresses the expression of the bone formation inhibitor sclerostin (Sost) in osteocytes by inducing… (More)
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2013
2013
Kallistatin antagonizes Wnt/β-catenin signaling and cancer cell motility via binding to low-density lipoprotein receptor-related protein 6
Kallistatin, a plasma protein, exerts pleiotropic effects in inhibiting angiogenesis, inflammation and tumor growth. Canonical… (More)
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2013
2013
miR-30e reciprocally regulates the differentiation of adipocytes and osteoblasts by directly targeting low-density lipoprotein receptor-related protein 6
Reciprocal relationship usually exists between osteoblastogenesis and adipogenesis, with factors stimulating one of these… (More)
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Highly Cited
2012
Highly Cited
2012
Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes
Wnt signaling plays critical roles in development of various organs and pathogenesis of many diseases, and augmented Wnt… (More)
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2009
2009
Helicobacter pylori-induced activation of β-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled
The human microbial pathogen Helicobacter pylori resides in the stomach of about fifty percent of the world's population and… (More)
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2009
2009
A common variant in low-density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-cholesterol.
OBJECTIVE A rare mutation in low-density lipoprotein receptor-related protein 6 gene (LRP6) was identified as the primary… (More)
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Highly Cited
2007
Highly Cited
2007
Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease.
Genome-wide linkage studies have defined a broad susceptibility region for late-onset Alzheimer's disease on chromosome 12, which… (More)
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Highly Cited
2007
Highly Cited
2007
Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation.
Multiple signaling pathways, including Wnt signaling, participate in animal development, stem cell biology, and human cancer… (More)
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2006
2006
The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity.
Glycogen synthase kinase 3 (GSK3) is a widely expressed Ser/Thr protein kinase that phosphorylates numerous substrates. This… (More)
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2005
2005
Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6.
A cranial neural tube defect in Crooked tail (Cd) mice is prevented with prenatal dietary folic acid Cd positional cloning… (More)
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