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LRP6 gene

Known as: Low Density Lipoprotein Receptor-Related Protein 6 Gene, LRP6, LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6 
This gene plays a role in signaling and endocytosis.
National Institutes of Health

Related topics

Related topics

6 relations
Intercellular Communication ProcessLRP6 protein, humanLigand BindingReceptor Mediated Endocytosis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Functional Characterization of a Small-Molecule Inhibitor of the DKK1-LRP6 Interaction
Background. DKK1 antagonizes canonical Wnt signalling through high-affinity binding to LRP5/6, an essential component of the Wnt… 
Review
2012
Review
2012
Endocytic receptor-mediated control of morphogen signaling
Receptor-mediated endocytosis provides a mechanism by which cells take up signaling molecules from the extracellular space… 
Highly Cited
2011
Highly Cited
2011
LRP6 Mediates cAMP Generation by G Protein–Coupled Receptors Through Regulating the Membrane Targeting of Gαs
The receptor LRP6 associates with Gαs to promote cAMP signaling by various GPCRs. Unexpected Partner Signaling by heterotrimeric… 
2008
2008
Multiple PPPS/TP motifs act in a combinatorial fashion to transduce Wnt signaling through LRP6
Highly Cited
2007
Highly Cited
2007
Analysis of Endogenous LRP6 Function Reveals a Novel Feedback Mechanism by Which Wnt Negatively Regulates Its Receptor
ABSTRACT The canonical Wnt pathway plays a crucial role in embryonic development, and its deregulation is involved in human… 
2007
2007
Requirement for natively unstructured regions of mesoderm development candidate 2 in promoting low-density lipoprotein receptor-related protein 6 maturation.
Proteins of the low-density lipoprotein receptor family (LRPs) are complex, multimodular type I transmembrane receptors… 
Highly Cited
2007
Highly Cited
2007
Gene Expression Signature and the Prediction of Ulcerative Colitis–Associated Colorectal Cancer by DNA Microarray
Purpose: Ulcerative colitis (UC) is associated with a high risk of colorectal cancer. To identify genes that could predict the… 
2007
2007
Regulated proteolytic processing of LRP6 results in release of its intracellular domain
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a member of low‐density lipoprotein receptor (LDLR) family which… 
2006
2006
Modulation of LRP6‐mediated Wnt signaling by molecular chaperone Mesd
Highly Cited
2005
Highly Cited
2005
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
Wnt co-receptors LRP5 and LRP6 are two members of the low-density lipoprotein receptor family. Receptor-associated protein is not… 
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