FAQ

lipopolysaccharide receptor complex

Known as: LPS receptor complex, LPS receptor complex location, lipopolysaccharide receptor complex location 
A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated and which functions as a… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1999-2017
0519992017

Related topics

Related topics

1 relation

Broader (1)

integral to membrane

Related mentions per year

Related mentions per year

1996-2018
1990200020102020
lipopolysaccharide receptor complex
integral to membrane

Papers overview

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2009
2009
IL-33 enhances lipopolysaccharide-induced inflammatory cytokine production from mouse macrophages by regulating lipopolysaccharide receptor complex.
Bacterial LPS triggers monocytes and macrophages to produce several inflammatory cytokines and mediators. However, once exposed… (More)
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Highly Cited
2006
Highly Cited
2006
Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity.
Immune responses are initiated when molecules of microbial origin are sensed by the Toll-like receptors (TLRs). We now report the… (More)
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Highly Cited
2002
Highly Cited
2002
Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections.
Human toll-like receptor 4 (hTLR4) and CD14 are known to be components of the lipopolysaccharide receptor complex. Our study… (More)
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Highly Cited
2002
Highly Cited
2002
Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells.
Prior exposure to LPS induces a transient state of cell refractoriness to subsequent LPS restimulation, known as endotoxin… (More)
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Highly Cited
2001
Highly Cited
2001
Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2.
The structural features of some proteins of the innate immune system involved in mediating responses to microbial pathogens are… (More)
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Highly Cited
2001
Highly Cited
2001
MIF regulates innate immune responses through modulation of Toll-like receptor 4.
Macrophages are pivotal effector cells of the innate immune system, which is vital for recognizing and eliminating invasive… (More)
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Highly Cited
2000
Highly Cited
2000
Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide.
Lipopolysaccharide (LPS) is the main inducer of shock and death in Gram-negative sepsis. Recent evidence suggests that LPS… (More)
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Highly Cited
2000
Highly Cited
2000
MD-2 binds to bacterial lipopolysaccharide.
The exact roles and abilities of the individual components of the lipopolysaccharide (LPS) receptor complex of proteins remain… (More)
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Highly Cited
1999
Highly Cited
1999
Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes.
Bacterial lipopolysaccharide (LPS)-mediated immune responses, including activation of monocytes, macrophages, and endothelial… (More)
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Highly Cited
1999
Highly Cited
1999
Signaling events induced by lipopolysaccharide-activated toll-like receptor 2.
Human Toll-like receptor 2 (TLR2) is a signaling receptor that responds to LPS and activates NF-kappaB. Here, we investigate… (More)
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