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linogliride

Known as: N-(1-Methyl-2-pyrrolidinylidene)-N'-phenyl-4-morpholinecarboxamidine 
A guanidine-based insulin secratogogue and structural analogue of pirogliride with hypoglycemic activity. Linogliride blocks ATP-sensitive potassium… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Pyrrolidines
linogliride fumarate

Papers overview

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2017
2017
The preparation and evaluation of salt forms of linogliride with reduced solubilities as candidates for extended release
Abstract Salts of linogliride with reduced solubilities were prepared and evaluated as potential candidates for extended-release… 
1999
1999
An in vitro model for screening oral hypoglycemics
Dear Editor: The majority of noninsulin-dependent type II diabetics are treated with oral hypoglycemics which induce insulin… 
1995
1995
Biotransformation of linogliride, a hypoglycemic agent in laboratory animals and humans.
1993
1993
A novel series of N-(1-aminoalkylidene)carboximidamides as potential hypoglycemic agents.
Nitrogen heterocyclic carboximidamides, such as linogliride, 1a, have been shown to possess significant hypoglycemic activity and… 
1991
1991
Effect of Linogliride on Hormone release From Perfused Rat Pancreas: Fuel Dependence and Desensitization by Tolbutamide
We examined the effect of the hypoglycemic drug linogliride on hormone release from the in vitro perfused rat pancreas… 
1989
1989
Postreceptor Regulation of Insulin Action in Primary Cultures of Rat Hepatocytes by Oral Hypoglycemic Agents: Effects of Linogliride and Chlorpropamide
We have previously demonstrated the ability of the sulfonylurea tolazamide to potentiate insulin action in primary cultures of… 
1987
1987
Influence of the oral hypoglycemic agent linogliride (McN-3935) on insulin secretion from isolated rat islets of Langerhans.
The influence of a new orally effective hypoglycemic compound, linogliride (McN-3935), on insulin release from isolated perifused… 
1986
1986
Pharmacologic profile and insulin secretagogue effect of linogliride (McN‐3935), a new, orally effective hypoglycemic agent
Linogliride (McN‐3935) [N‐(1‐methyl‐2‐pyrrolidinylidene)‐N'‐phenyl‐4‐morpholinecarboximidamide] was selected for clinical… 
1986
1986
Metabolism of linogliride (Lg) in the rat, dog and man
Lg, N-(1-methyl-2-pyrrolidinylidene)-N'-phenyl-4-morpho-linecarboximidamide, is a new hypoglycemic drug. Following oral… 
1986
1986
Process for producing guanidines such as linogliride and process for intermediates
New synthesis intermediates generated and guanidines such as anti-diabetic compound linogliride, including hydrogen peroxide… 
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