ligase activity

Known as: synthetase activity 
Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Missense mutations in PTEN-induced kinase 1 (PINK1) cause autosomal-recessive inherited Parkinson's disease (PD). We have… (More)
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Highly Cited
2008
Highly Cited
2008
Inhibitor of Apoptosis Proteins (IAPs) can bind to and inhibit caspases, the key executioners of apoptosis. Because IAPs are… (More)
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Highly Cited
2007
Highly Cited
2007
The RING domain of MDM2 that is essential for its E3 ligase activity mediates binding to itself and its structural homologue MDMX… (More)
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Highly Cited
2006
Highly Cited
2006
The control of p53 ubiquitination by MDM2 provides a model system to define how an E3-ligase functions on a conformationally… (More)
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Highly Cited
2004
Highly Cited
2004
Parkin is an E3 ubiquitin ligase involved in the ubiquitination of proteins that are important in the survival of dopamine… (More)
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Highly Cited
2002
Highly Cited
2002
The assumption that each enzyme expresses a single enzymatic activity in vivo is challenged by the linkage of the neuronal enzyme… (More)
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Review
2002
Review
2002
Although the protein product of the BRCA1 tumor suppressor gene has been implicated in a surprisingly diverse array of biological… (More)
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Highly Cited
2000
Highly Cited
2000
Huntington disease is an autosomal dominant neurodegenerative disease with no effective treatment. Minocycline is a tetracycline… (More)
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Highly Cited
1990
Highly Cited
1990
Nitric oxide mediates vascular relaxing effects of endothelial cells, cytotoxic actions of macrophages and neutrophils, and… (More)
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Review
1987
Review
1987
Arachidonic acid is released from membrane phospholipids upon cell stimulation (for example, by immune complexes and calcium… (More)
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