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lavendamycin

Known as: 9H-Pyrido(3,4-b)indole-3-carboxylic acid, 1-(7-amino-5,8-dihydro-5,8-dioxo-2-quinolinyl)-4-methyl- 
National Institutes of Health

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Broader (1)

Streptonigrin
analogs & derivatives

Papers overview

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2014
2014
Significance of agitation-induced shear stress on mycelium morphology and lavendamycin production by engineered Streptomyces flocculus
Lavendamycin methyl ester (LME) is a derivative of a highly functionalized aminoquinone alkaloid lavendamycin and could be used… 
2013
2013
MECHANISMS AND CYTOTOXIC EFFECTS OF NQO1-DIRECTED LAVENDAMYCIN DERIVATIVES AND MITOCHONDRIA-TARGETED ANTHRACENYL ISOXAZOLE AMIDES AS NOVEL ANTITUMOR AGENTS
A series of 7-aminoand 7-acetamidoquinoline-5,8-diones with aryl substituents at the 2position were synthesized, characterized… 
2009
2009
Total synthesis of Lavendamycin derivatives : an honors thesis (HONRS 499)
Derivatives of Lavendamycin, an antitumor antibiotic natural product, were synthesized via short and efficient methods. Pictet… 
2007
2007
Synthesis and evaluation of antitumor activity of novel N-acyllavendamycin analogues and quinoline-5,8-diones.
2007
2007
NAD(P)H:quinone oxidoreductase (NQO1)-directed lavendamycin antitumor agents: Structure-based design, molecular modeling and structure-activity studies
iii Acknowledgements iv Table of 
2003
2003
Siloxane-based cross-coupling of bromopyridine derivatives: studies for the synthesis of streptonigrin and lavendamycin.
Highly functionalized 4-bromopyridines were prepared and found to undergo fluoride-promoted, Pd-catalyzed cross-coupling with… 
2003
2003
--Total Synthesis of 7N-Succinyldemethyllavendamycin Esters
7-N-Succinyldemethyllavendamycin esters-analogs of the naturally occurring, anti-tumor, anti-microbial agent lavendamycin-were… 
2001
2001
Biologic effects of lavendamycin analogs on cultured cells and HIV-RT
1993
1993
Novel cytocidal compounds, oxopropalines from Streptomyces sp. G324 producing lavendamycin. I. Taxonomy of the producing organism, fermentation, isolation and biological activities.
In the course of our investigation aimed at the discovery of novel antitumor antibiotics from microorganisms, Streptomyces sp… 
1986
1986
In vitro oxidation of the 8-hydroxyquinoline moiety with metabolic activation system to a mutagenic quinoloquinone compound of lavendamycin analogs.
Intermediary products in the synthesis of lavendamycin were tested for mutagenic activities in Salmonella typhimurium TA 98 and… 
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