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lavendamycin

Known as: 9H-Pyrido(3,4-b)indole-3-carboxylic acid, 1-(7-amino-5,8-dihydro-5,8-dioxo-2-quinolinyl)-4-methyl- 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Streptonigrin
analogs & derivatives

Papers overview

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Highly Cited
2010
Highly Cited
2010
Heteroaryl cross-coupling as an entry toward the synthesis of lavendamycin analogues: a model study.
ABC analogues of the antitumor antibiotic lavendamycin, which contain the key metal chelation site and redox-active quinone unit… 
Highly Cited
2008
Highly Cited
2008
Gold-catalyzed cycloisomerization of N-Propargylindole-2-carboxamides: application toward the synthesis of lavendamycin analogues.
A series of N-propargylindole-2-carboxamides were found to undergo a AuCl 3-catalyzed cycloisomerization to give beta… 
2008
2008
Lavendamycin antitumor agents: structure-based design, synthesis, and NAD(P)H:quinone oxidoreductase 1 (NQO1) model validation with molecular docking and biological studies.
A 1H69 crystal structure-based in silico model of the NAD(P)H:quinone oxidoreductase 1 (NQO1) active site has been developed to… 
2007
2007
Synthesis and evaluation of antitumor activity of novel N-acyllavendamycin analogues and quinoline-5,8-diones.
Highly Cited
2005
Highly Cited
2005
Novel lavendamycin analogues as antitumor agents: synthesis, in vitro cytotoxicity, structure-metabolism, and computational molecular modeling studies with NAD(P)H:quinone oxidoreductase 1.
Novel lavendamycin analogues with various substituents were synthesized and evaluated as potential NAD(P)H:quinone oxidoreductase… 
2003
2003
Siloxane-based cross-coupling of bromopyridine derivatives: studies for the synthesis of streptonigrin and lavendamycin.
Highly functionalized 4-bromopyridines were prepared and found to undergo fluoride-promoted, Pd-catalyzed cross-coupling with… 
2003
2003
Novel lavendamycin analogues as potent HIV-reverse transcriptase inhibitors: synthesis and evaluation of anti-reverse transcriptase activity of amide and ester analogues of lavendamycin.
Novel lavendamycins including two water soluble derivatives were synthesized via short and efficient methods. Pictet-Spengler… 
2003
2003
Characterization of the cytotoxic activities of novel analogues of the antitumor agent, lavendamycin.
Lavendamycin is a bacterially derived quinolinedione that displays significant antimicrobial and antitumor activities. However… 
Highly Cited
1987
Highly Cited
1987
Streptonigrin and lavendamycin partial structures. Probes for the minimum, potent pharmacophore of streptonigrin, lavendamycin, and synthetic quinoline-5,8-diones.
The preparation and evaluation of 7-amino-5,8-dioxo-2-(2'-pyridyl)quinoline-6'-carboxylic acid (5a) and 7-amino-2-(2'-aminophenyl… 
Highly Cited
1982
Highly Cited
1982
Isolation of lavendamycin, a new antibiotic from Streptomyces lavendulae.
The isolation of lavendamycin (1) an antibiotic closely related to streptonigrin (2) is described. Details of the taxonomic… 
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