Streptonigrin

Known as: Streptonigrin [Chemical/Ingredient], Brunemycin, 5-Amino-6-(70-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic Acid 
An aminoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces flocculus. Streptonigrin complexes with DNA and topoisomerase II… (More)

Topic mentions per year

Topic mentions per year

1959-2017
010020019592017

Papers overview

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Review
2016
Review
2016
The striatum and the subthalamic nucleus (STN) are two separate input structures into the basal ganglia (BG). Accordingly… (More)
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Highly Cited
2007
Highly Cited
2007
The ability to stop motor responses depends critically on the right inferior frontal cortex (IFC) and also engages a midbrain… (More)
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Highly Cited
2007
Highly Cited
2007
Gait disturbances and akinesia are extremely disabling in advanced Parkinson's disease. It has been suggested that modulation of… (More)
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Highly Cited
2006
Highly Cited
2006
Suppressing an already initiated manual response depends critically on the right inferior frontal cortex (IFC), yet it is unclear… (More)
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Highly Cited
2006
Highly Cited
2006
The basal ganglia (BG) coordinate decision making processes by facilitating adaptive frontal motor commands while suppressing… (More)
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Highly Cited
2005
Highly Cited
2005
Deep brain stimulation (DBS) is associated with significant improvement of motor complications in patients with severe Parkinson… (More)
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Highly Cited
2003
Highly Cited
2003
To clarify the mechanism underlying improvement of parkinsonian signs by high-frequency electrical stimulation (HFS) of the… (More)
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Highly Cited
2001
Highly Cited
2001
The extent of synchronization within and between the nuclei of the basal ganglia is unknown in Parkinson's disease. The question… (More)
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Highly Cited
1999
Highly Cited
1999
The subthalamic nucleus of the basal ganglia (STN) is important for normal movement as well as in movement disorders. Lesioning… (More)
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Highly Cited
1994
Highly Cited
1994
1. The neuronal mechanisms underlying the major motor signs of Parkinson's disease were studied in the basal ganglia of… (More)
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