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larotaxel

A semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting… 
National Institutes of Health

Related topics

Related topics

4 relations
Microtubule Process

Narrower (2)

RPR 109881AXRP 9881

Broader (1)

Taxoids

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
Targeted Delivery of Nanoparticle Based Taxanes for Breast Cancer Treatment: A Review
The most common type of cancers in women is breast cancer. In United States, it is the second common cause of death in women… 
2018
2018
Characterization of metabolites of larotaxel in rat by liquid chromatography coupled with Q exactive high-resolution benchtop quadrupole orbitrap mass spectrometer
Abstract 1. Liquid-chromatography (LC) high-resolution (HR) mass spectrometry (MS) analysis can record HR full scans for drug… 
2017
2017
Pharmacokinetics and tissue distribution of larotaxel in rats: comparison of larotaxel solution with larotaxel-loaded folate receptor-targeting amphiphilic copolymer-modified liposomes
Abstract 1. The aim of this study was to compare the pharmacokinetics (PKs) and tissue distribution of larotaxel (LTX) solution… 
2013
2013
A sensitive liquid chromatography-mass spectrometry method for simultaneous determination of three diterpenoid esters from Euphorbia lathyris L. in rat plasma.
2012
2012
Development of a UPLC-ESI-MS/MS method for the determination of larotaxel in beagle dog plasma: application to the pharmacokinetic study
AbstractA UPLC-ESI-MS/MS method has been developed and validated for the determination of larotaxel in beagle dog plasma. After… 
Review
2009
Review
2009
Anthracycline- and/or taxane-resistant breast cancer: results of a literature review to determine the clinical challenges and current treatment trends.
Review
2009
Review
2009
Systemic Therapy of Advanced Urothelial Cancer
Opinion statementAdvanced bladder/urothelial cancer remains an incurable terminal disease, and accounts for 3% of the cancer… 
Review
2009
Review
2009
Epothilones: better or more of the same?
Agents that interfere with microtubule structure and function continue to play a major role in cancer treatment. The vinca… 
2008
2008
Larotaxel (L) in combination with trastuzumab in patients with HER2 + metastatic breast cancer (MBC): Interim analysis of an open phase II label study
1070 Background: Larotaxel (L), a semi-synthetic taxoid, has shown preclinical and clinical activity against taxane-resistant BC… 
2007
2007
In vivo synergy between trastuzumab (herceptin ® ) and larotaxel (RPR 109881A), a new taxoid.
1432 Larotaxel (RPR 109881A/XRP9881) is a taxoid, that is currently in development for breast cancer and other tumor types. Like… 
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