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Although many vertebrate organs, such as kidneys, lungs and liver, are composed of epithelial tubules, little is known of the… Expand Mammalian kidney morphogenesis begins when the ureteric bud (UB) induces surrounding metanephric mesenchyme to differentiate into… Expand Epithelial-mesenchymal interactions are required for the development of all solid organs but few molecular mechanisms that… Expand Epithelio-mesenchymal interactions during kidney organogenesis are disrupted in integrin alpha8 beta1-deficient mice. However… Expand We present genetic evidence that integrins regulate epithelial–mesenchymal interactions during organogenesis. Mice with a… Expand The development of the mature mammalian kidney begins with the invasion of metanephric mesenchyme by ureteric bud. Mesenchymal… Expand Metanephric mesenchyme gives rise to both the epithelial cells of the nephron and the stromal cells of the mature kidney. The… Expand The receptor tyrosine kinase RET functions during the development of the kidney and the enteric nervous system, yet no ligand has… Expand The developmental, regulatory gene Pax-2 is activated during early kidney morphogenesis and repressed in mature renal epithelium… Expand Nerve growth factor receptor (NGFR) serves as the binding site for the neurotrophic growth factors. Although NGFR has been found… Expand