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Wnt-4 deficiency alters mouse adrenal cortex function, reducing aldosterone production.
TLDR
A role for Wnt-4 in adrenal gland development and function is pointed to, and some cells that are positive for Cyp21, which is normally expressed only in the adrenal glands, are found in the gonads of WNT-4-deficient embryos, indicating that Wnt -4 may play a role in cell migration or in the sorting of adrenal and gonadal cells during early development. Expand
Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure.
TLDR
The results suggest that a new cardiac regulatory peptide, apelin, and APJ receptor may contribute to the pathophysiology of human CHF. Expand
Mechanisms of atrial and brain natriuretic peptide release from rat ventricular myocardium: effect of stretching.
TLDR
It is indicated that stretch stimulates both ANP and BNP secretion from hypertropic ventricular myocytes, and the results suggest that protein kinase-C may be involved in stretch-induced ventricular ANP release, whereas the influx of extracellular calcium may not be necessary. Expand
Molecular heterogeneity has a major impact on the measurement of circulating N-terminal fragments of A- and B-type natriuretic peptides.
TLDR
Molecular heterogeneity of the circulating forms causes a serious risk of preanalytical errors in assays for NT-proBNP and, to a lesser extent,NT-proANP. Expand
Hypoxia inducible factor regulates the cardiac expression and secretion of apelin
TLDR
It is shown that hypoxia increases the apelin expression in rat myocardium and in cultured cardiomyocytes, suggesting a role for apelin as a potential marker for acute cardiac Hypoxia with a possible compensatory role in myocardial tissue suffering from oxygen deprivation. Expand
Involvement of transcriptional and posttranscriptional mechanisms in cardiac overload-induced increase of B-type natriuretic peptide gene expression.
TLDR
It is demonstrated that the early increase of BNP mRNA levels by mechanical stretch results from increased transcriptional activation and is independent of protein synthesis, suggesting that protein kinase C and tyrosine kinases activities may be involved in coupling cardiac overload to alterations in atrial BNP synthesis. Expand
Brain natriuretic peptide in plasma, atria, and ventricles of vasopressin- and phenylephrine-infused conscious rats.
TLDR
The present study shows that pressure overload rapidly stimulates BNP gene expression in the hearts of normal and hypertensive rats, and locally generated BNP in the heart muscle may play a significant role in cardiac adaptation to acute changes in mechanical load. Expand
Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart
TLDR
It is concluded that apela is present in the adult heart, is upregulated in post-infarction cardiac remodeling, and increases cardiac contractility in an ERK1/2-dependent manner. Expand
Ghrelin induces vasoconstriction in the rat coronary vasculature without altering cardiac peptide secretion.
TLDR
The first evidence that ghrelin has a coronary vasoconstrictor action that is dependent on Ca(2+) and PKC is provided and the observation that immunoreactive gh Relin is found in cardiac tissue suggests the presence of a local cardiacghrelin system. Expand
Natriuretic peptides as predictors of non-sudden and sudden cardiac death after acute myocardial infarction in the beta-blocking era.
TLDR
Natriuretic peptides retain their prognostic value in the beta-blocking era among survivors of AMI, and elevated BNP provides information on the risk of subsequent SCD, independent of clinical variables and left ventricular EF. Expand
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