ivacaftor

Known as: 3-quinolinecarboxamide, N-(2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl)-1,4-dihydro-4-oxo-, N-(2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide, N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2011-2017
0204020112017

Papers overview

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Highly Cited
2014
Highly Cited
2014
BACKGROUND The phe508del CFTR mutation causes cystic fibrosis by limiting the amount of CFTR protein that reaches the epithelial… (More)
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Highly Cited
2014
Highly Cited
2014
RATIONALE Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator recently approved for patients… (More)
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Highly Cited
2014
Highly Cited
2014
BACKGROUND Ivacaftor (KALYDECO™, VX-770) is a CFTR potentiator that increased CFTR channel activity and improved lung function in… (More)
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2014
2014
BACKGROUND We examined data from a Phase 2 trial {NCT00457821} of ivacaftor, a CFTR potentiator, in cystic fibrosis (CF) patients… (More)
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Highly Cited
2013
Highly Cited
2013
RATIONALE Ivacaftor (VX-770), a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, has been shown to improve… (More)
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2013
2013
BACKGROUND Ivacaftor has shown a clinical benefit in patients with cystic fibrosis who have the G551D-CFTR mutation and reduced… (More)
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2013
2013
Cystic fibrosis (CF) is a life-shortening inherited disease caused by mutations in the CF transmembrane conductance regulator… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND The investigational CFTR potentiator ivacaftor (VX-770) increased CFTR channel activity and improved lung function in… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Ivacaftor (VX-770) is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator that was approved in… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Increasing the activity of defective cystic fibrosis transmembrane conductance regulator (CFTR) protein is a potential… (More)
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