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isotrichodermin

 
National Institutes of Health

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Trichothecenes

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2016
2016
Hydroxylations of trichothecene rings in the biosynthesis of Fusarium trichothecenes: evolution of alternative pathways in the nivalenol chemotype.
Fusarium sporotrichioides genes FsTri11, FsTri13, and FsTri1 encode cytochrome P450 monooxygenases (CYPs) responsible for… Expand
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Highly Cited
2006
Highly Cited
2006
Fusarium Tri4 encodes a multifunctional oxygenase required for trichothecene biosynthesis.
Fusarium graminearum and Fusarium sporotrichioides produce the trichothecene mycotoxins 15-acetyldeoxynivalenol and T-2 toxin… Expand
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2006
2006
Heterologous expression of two trichothecene P450 genes in Fusarium verticillioides.
Fusarium graminearum Z-3639 and F. sporotrichioides NRRL3299 produce the trichothecene mycotoxins 15-acetyldeoxynivalenol and T-2… Expand
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Highly Cited
1999
Highly Cited
1999
Disruption of TRI101, the Gene Encoding Trichothecene 3-O-Acetyltransferase, fromFusarium sporotrichioides
ABSTRACT We screened a Fusarium sporotrichioides NRRL 3299 cDNA expression library in a toxin-sensitive Saccharomyces cerevisiae… Expand
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Highly Cited
1998
Highly Cited
1998
The TRI11 Gene of Fusarium sporotrichioides Encodes a Cytochrome P-450 Monooxygenase Required for C-15 Hydroxylation in Trichothecene Biosynthesis
ABSTRACT Several genes in the trichothecene biosynthetic pathway ofFusarium sporotrichioides have been shown to reside in a gene… Expand
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1997
1997
Accumulation of Trichothecenes in Liquid Cultures of a Fusarium sporotrichioides Mutant Lacking a Functional Trichothecene C-15 Hydroxylase.
A mutant strain of Fusarium sporotrichioides NRRL 3299 produced by disruption of Tri11, a gene encoding a cytochrome P-450… Expand
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1996
1996
Biosynthesis of the trichothecene 3-acetyldeoxynivalenol: cell-free hydroxylations of isotrichodermin.
3-Acetyldeoxynivalenol is the major trichothecene produced by the fungus Fusarium culmorum. Studies in vivo with F. culmorum have… Expand
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1996
1996
Biosynthesis of the Trichothecene 3-Acetyldeoxynivalenol
3-Acetyldeoxynivalenol is the major trichothecene produced by the fungus Fusarium culmorum. The first proven tricyclic… Expand
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1991
1991
Biosynthesis of the trichothecene 3-acetyldeoxynivalenol. Identification of the oxygenation steps after isotrichodermin.
Upon feeding an excess of the substrate isotrichodermin, five tricyclic metabolites accumulated in Fusarium culmorum cultures… Expand
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1990
1990
Biosynthesis of Fusarium culmorum trichothecenes. The roles of isotrichodermin and 12,13-epoxytrichothec-9-ene.
Two different approaches enabled us to unambiguously establish the intermediacy of isotrichodermin and 12,13-epoxytrichothec-9… Expand
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