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isopenicillin N

National Institutes of Health

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penicillin N

Papers overview

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2013
2013
The Interaction of Isopenicillin N Synthase with Homologated Substrate Analogues δ‐(L‐α‐Aminoadipoyl)‐L‐homocysteinyl‐D‐Xaa Characterised by Protein Crystallography
Isopenicillin N synthase (IPNS) converts the linear tripeptide δ‐(L‐α‐aminoadipoyl)‐L‐cysteinyl‐D‐valine (ACV) into bicyclic… 
2012
2012
Homology modeling of the structure of acyl coA:isopenicillin N-acyltransferase (IAT) from Penicillium chrysogenum. IAT interaction studies with isopenicillin-N, combining molecular dynamics…
In the last step of penicillin biosynthesis, acyl-CoA:isopenicillin N acyltransferase (IAT) (E.C. 2.3.1.164) catalyzes the… 
2011
2011
Isopenicillin N Synthase Binds δ‐(L‐α‐Aminoadipoyl)‐L‐Cysteinyl‐D‐Thia‐allo‐Isoleucine through both Sulfur Atoms
Isopenicillin N synthase (IPNS) catalyses the synthesis of isopenicillin N (IPN), the biosynthetic precursor to penicillin and… 
2011
2011
A preparative method for the purification of isopenicillin N from genetically blocked Acremonium chrysogenum strain TD189: studies on the degradation kinetics and storage conditions
A protocol for preparative isopenicillin N (IPN) purification, a highly interesting and hitherto unavailable intermediate of the… 
2010
2010
The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase.
Isopenicillin N synthase (IPNS) is a non-heme iron(ii) oxidase, which catalyses the biosynthesis of isopenicillin N (IPN) from… 
2009
2009
Structural Studies on the Reaction of Isopenicillin N Synthase with a Sterically Demanding Depsipeptide Substrate Analogue
Isopenicillin N synthase (IPNS) is a nonheme iron(II)‐dependent oxidase that catalyses the central step in penicillin… 
2009
2009
Chapter 16. Enzymology of beta-lactam compounds with cephem structure produced by actinomycete.
2007
2007
In vivo transport of the intermediates of the penicillin biosynthetic pathway in tailored strains of Penicillium chrysogenum
Penicillium chrysogenum npe10 (Δpen; lacking the 56.8-kbp amplified region containing the penicillin gene cluster), complemented… 
2001
2001
Effect of mannan and alginate oligosaccharides on production in bioreactors of penicillin G and its biosynthetic intermediates
The addition of alginate and mannan oligosaccharides to Penicillium chryso- genum was examined to determine their effects on the… 
Review
1998
Review
1998
New aspects of genes and enzymes for beta-lactam antibiotic biosynthesis.
Penicillins, cephalosporins and cephamycins are peptide antibiotics synthesized by condensation of L-alpha-aminoadipic acid, L… 
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