isometamidium

Objective  To determine the drug resistance of Trypanosoma brucei rhodesiense strains isolated from sleeping sickness patients in… Expand

Sleeping sickness is an increasing problem in many parts of sub-Saharan Africa. The problems are compounded by the lack of new… Expand

Thirty‐six Trypanosoma brucei spp. stocks isolated from man and domestic animals in south‐east Uganda were studied for… Expand

Resistance to isometamidium was increased 94-fold in a clone of Trypanosoma congolense (clone IL 1180) by repeated subcurative… Expand

The drug sensitivity of seven Trypanosoma vivax-isolates from Kenya and Somalia was examined. With the exception of diminazene… Expand

Glossina infected with African trypanosomes infest 107 Km2 of intertropical Africa. Ten thousand cases of human sleeping sickness… Expand

The frequent reappearance of patent parasitemia, mainly Trypanosoma congolense, in cattle maintained under isometamidium… Expand

Concentrations of isometamidium in goat tissues were examined at intervals following a single intravenous or intramuscular dose… Expand

Summary Isometamidium leaves the blood rapidly in rats after i.v. injection and within a few minutes most of the compound is… Expand

THE trypanocidal drug, metamidium, first described by Wragg, Washbourn, Brown and Hill1, was obtained from the coupling reaction… Expand