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isometamidium

Known as: 8-(3-(M-Amidinophenyl)-2-Triazeno)-3-Amino-5-Ethyl-6-Phenylphenanthridinium, isometamidium ion, isometamidium cation 
 
National Institutes of Health

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isometamidium chloride

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2016
2016
Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F1Fo-ATPase
Background Isometamidium is the main prophylactic drug used to prevent the infection of livestock with trypanosomes that cause… Expand
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2015
2015
Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes
Significance Anti-trypanosomal drugs, used to tackle lethal human and animal diseases, target an unusual parasite DNA structure… Expand
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2006
2006
Drug-resistance of Trypanosoma b. rhodesiense isolates from Tanzania.
OBJECTIVE To determine the drug resistance of Trypanosoma brucei rhodesiense strains isolated from sleeping sickness patients in… Expand
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Review
2001
Review
2001
Transporters in African trypanosomes: role in drug action and resistance.
Sleeping sickness is an increasing problem in many parts of sub-Saharan Africa. The problems are compounded by the lack of new… Expand
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1997
1997
Susceptibility of Ugandan Trypanosoma brucei rhodesiense isolated from man and animal reservoirs to diminazene, isometamidium and melarsoprol.
Thirty-six Trypanosoma brucei spp. stocks isolated from man and domestic animals in south-east Uganda were studied for… Expand
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1997
1997
Cross-resistance associated with development of resistance to isometamidium in a clone of Trypanosoma congolense.
Resistance to isometamidium was increased 94-fold in a clone of Trypanosoma congolense (clone IL 1180) by repeated subcurative… Expand
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1991
1991
Reduced accumulation of isometamidium by drug-resistant Trypanosoma congolense.
The accumulation of the trypanocide isometamidium chloride (Samorin, RMB Animal Health Ltd., UK) by a range of clones of… Expand
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1984
1984
The appearance of isometamidium resistant Trypanosoma congolense in West Africa.
The frequent reappearance of patent parasitemia, mainly Trypanosoma congolense, in cattle maintained under isometamidium… Expand
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1980
1980
Isometamidium residues in goat tissues after parenteral administration.
Concentrations of isometamidium in goat tissues were examined at intervals following a single intravenous or intramuscular dose… Expand
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1967
1967
Physiologic disposition and intracellular localization of isometamidium.
Summary Isometamidium leaves the blood rapidly in rats after i.v. injection and within a few minutes most of the compound is… Expand
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