FAQ

isocitrate dehydrogenase activity

Known as: IDH activity, isocitric acid dehydrogenase activity, beta-ketoglutaric-isocitric carboxylase activity 
Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor. [EC:1.1.1.41, EC:1.1.1.42]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1952-2017
051019522016

Papers overview

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Highly Cited
2010
Highly Cited
2010
The prognostic IDH1R132 mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma
Somatic mutations in the isocitrate dehydrogenase 1 gene (IDH1) occur at high frequency in gliomas and seem to be a prognostic… (More)
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2007
2007
NAD-dependent isocitrate dehydrogenase mutants of Arabidopsis suggest the enzyme is not limiting for nitrogen assimilation.
NAD-dependent isocitrate dehydrogenase (IDH) is a tricarboxylic acid cycle enzyme that produces 2-oxoglutarate, an organic acid… (More)
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2005
2005
Regulation of mitochondrial NADP+-dependent isocitrate dehydrogenase activity by glutathionylation.
Recently, we demonstrated that the control of mitochondrial redox balance and oxidative damage is one of the primary functions of… (More)
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2002
2002
Bacillus subtilis isocitrate dehydrogenase. A substrate analogue for Escherichia coli isocitrate dehydrogenase kinase/phosphatase.
In Escherichia coli, the homodimeric Krebs cycle enzyme isocitrate dehydrogenase (EcIDH) is regulated by reversible… (More)
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2000
2000
NADP(+)-isocitrate dehydrogenase gene expression and isozyme activity during citrus fruit development.
The accumulation of citric acid and its decline toward fruit maturation is typical of citrus fruit. We studied NADP(+)-isocitrate… (More)
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1998
1998
IDP3 encodes a peroxisomal NADP-dependent isocitrate dehydrogenase required for the beta-oxidation of unsaturated fatty acids.
In Saccharomyces cerevisiae the metabolic degradation of saturated fatty acids is exclusively confined to peroxisomes. In… (More)
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1997
1997
Expression and mutagenesis of mammalian cytosolic NADP+-specific isocitrate dehydrogenase.
Rat liver cytosolic NADP+-specific isocitrate dehydrogenase (IDP2) was expressed in bacteria as a fusion protein with maltose… (More)
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Highly Cited
1994
Highly Cited
1994
Modulation of preparatory neuronal activity in dorsal premotor cortex due to stimulus-response compatibility.
1. Neuronal activity was recorded in the dorsal premotor cortex (PMd) of two monkeys performing a multidirectional, instructed… (More)
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Highly Cited
1993
Highly Cited
1993
Function and expression of yeast mitochondrial NAD- and NADP-specific isocitrate dehydrogenases.
The three isozymes of isocitrate dehydrogenase in Saccharomyces cerevisiae differ in subunit structure, subcellular location, and… (More)
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1979
1979
Phosphorylation of Isocitrate dehydrogenase of Escherichia coli.
Addition of acetate to a stationary phase culture of Escherichia coli in glycerol mineral salts medium containing phosphorus-32… (More)
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