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isepamicin

Known as: D-Streptamine, O-6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-N1-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-, (S)-, (2S)-3-amino-N-((1R,2S,3S,4R,5S)-5-amino-4-[(6-amino-6-deoxy-D-glucopyranosyl)oxy]-2-{[3-deoxy-4-C-methyl-3-(methylamino)-L-arabinopyranosyl]oxy}-3-hydroxycyclohexyl)-2-hydroxypropanamide, N-(S-3-amino-2-hydroxypropionyl)gentamicin 
A broad-spectrum aminoglycoside antibiotic structurally related to gentamicin and amikacin. Isepamicin has activity similar to amikacin but with… Expand
National Institutes of Health

Related topics

Related topics

7 relations

Broader (2)

Anti-Bacterial AgentsGentamicins

Narrower (4)

IsepacinSCH21420Sch 21420isepamicin sulfate
Isepamicin:Susc:Pt:Isolate:OrdQn:MIC

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
New plasmid-mediated aminoglycoside 6'-N-acetyltransferase, AAC(6')-Ian, and ESBL, TLA-3, from a Serratia marcescens clinical isolate.
OBJECTIVES Enterobacteriaceae clinical isolates showing amikacin resistance (MIC 64 to >256 mg/L) in the absence of 16S rRNA… Expand
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Highly Cited
2011
Highly Cited
2011
Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates.
BACKGROUND the emergence of carbapenemases in Enterobacteriaceae is driving a search for therapeutic alternatives. We tested ACHN… Expand
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2007
2007
PDE4D and ALOX5AP genetic variants and risk for Ischemic Cerebrovascular Disease in Sweden
BACKGROUND Genetic variants in Phosphodiesterase 4D (PDE4D) and 5-lipoxygenase activating protein (ALOX5AP) have been shown to… Expand
2005
2005
In vitro activities of tigecycline, ertapenem, isepamicin, and other antimicrobial agents against clinically isolated organisms in Taiwan.
This study evaluated the in vitro activities of tigecycline, ertapenem, isepamicin, and other comparators against 861 bacterial… Expand
Highly Cited
2005
Highly Cited
2005
Multidrug-Resistant Pseudomonas aeruginosa Strain That Caused an Outbreak in a Neurosurgery Ward and Its aac(6′)-Iae Gene Cassette Encoding a Novel Aminoglycoside Acetyltransferase
ABSTRACT We characterized multidrug-resistant Pseudomonas aeruginosa strains isolated from patients involved in an outbreak of… Expand
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Highly Cited
2001
Highly Cited
2001
Characterization of Class 1 Integrons from Pseudomonas aeruginosa That Contain the blaVIM-2Carbapenem-Hydrolyzing β-Lactamase Gene and of Two Novel Aminoglycoside Resistance Gene Cassettes
ABSTRACT Two clonally unrelated Pseudomonas aeruginosa clinical strains, RON-1 and RON-2, were isolated in 1997 and 1998 from… Expand
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Highly Cited
2000
Highly Cited
2000
Apoptosis in Renal Proximal Tubules of Rats Treated with Low Doses of Aminoglycosides
ABSTRACT Kidney cortex apoptosis was studied with female Wistar rats treated for 10 days with gentamicin and netilmicin at daily… Expand
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Highly Cited
1999
Highly Cited
1999
Semisynthetic aminoglycoside antibiotics: Development and enzymatic modifications
  • S. Kondo, K. Hotta
  • Journal of infection and chemotherapy : official…
  • 1999
    • Corpus ID: 38981498
Abstract The critical resistance mechanisms of aminoglycoside antibiotics in bacteria of clinical importance are the enzymatic N… Expand
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Highly Cited
1998
Highly Cited
1998
Synthesis of antibiotic-loaded interporous hydroxyapatite blocks by vacuum method and in vitro drug release testing.
Interporous hydroxyapatite ceramic (Ca10(PO4)6(OH)2) has excellent bio-compatibility and interlinked pore structure, antibiotics… Expand
Highly Cited
1993
Highly Cited
1993
In vitro antimicrobial production of beta-lactamases, aminoglycoside-modifying enzymes, and chloramphenicol acetyltransferase by and susceptibility of clinical isolates of Acinetobacter baumannii.
Antimicrobial susceptibility testing was performed on 54 epidemiologically unrelated clinical isolates of Acinetobacter baumannii… Expand
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