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isepamicin
Known as:
D-Streptamine, O-6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-N1-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-, (S)-
, (2S)-3-amino-N-((1R,2S,3S,4R,5S)-5-amino-4-[(6-amino-6-deoxy-D-glucopyranosyl)oxy]-2-{[3-deoxy-4-C-methyl-3-(methylamino)-L-arabinopyranosyl]oxy}-3-hydroxycyclohexyl)-2-hydroxypropanamide
, N-(S-3-amino-2-hydroxypropionyl)gentamicin
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A broad-spectrum aminoglycoside antibiotic structurally related to gentamicin and amikacin. Isepamicin has activity similar to amikacin but with…
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National Institutes of Health
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Related topics
Related topics
7 relations
Broader (2)
Anti-Bacterial Agents
Gentamicins
Narrower (4)
Isepacin
SCH21420
Sch 21420
isepamicin sulfate
Isepamicin:Susc:Pt:Isolate:OrdQn:MIC
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
New plasmid-mediated aminoglycoside 6'-N-acetyltransferase, AAC(6')-Ian, and ESBL, TLA-3, from a Serratia marcescens clinical isolate.
Wanchun Jin
,
J. Wachino
,
K. Kimura
,
Keiko Yamada
,
Y. Arakawa
The Journal of antimicrobial chemotherapy
2015
Corpus ID: 42122151
OBJECTIVES Enterobacteriaceae clinical isolates showing amikacin resistance (MIC 64 to >256 mg/L) in the absence of 16S rRNA…
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Highly Cited
2011
Highly Cited
2011
Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates.
D. Livermore
,
S. Mushtaq
,
+4 authors
N. Woodford
The Journal of antimicrobial chemotherapy
2011
Corpus ID: 14420374
BACKGROUND the emergence of carbapenemases in Enterobacteriaceae is driving a search for therapeutic alternatives. We tested ACHN…
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Review
2009
Review
2009
Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of stroke: a HuGE gene-disease association review and meta-analysis.
E. Zintzaras
,
P. Rodopoulou
,
Nikos N Sakellaridis
American journal of epidemiology
2009
Corpus ID: 16107396
Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene have been implicated as a risk factor for stroke…
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2007
2007
PDE4D and ALOX5AP genetic variants and risk for Ischemic Cerebrovascular Disease in Sweden
K. Kostulas
,
S. Grétarsdóttir
,
+8 authors
J. Hillert
Journal of the Neurological Sciences
2007
Corpus ID: 38081805
Highly Cited
2001
Highly Cited
2001
Characterization of Class 1 Integrons from Pseudomonas aeruginosa That Contain the blaVIM-2Carbapenem-Hydrolyzing β-Lactamase Gene and of Two Novel Aminoglycoside Resistance Gene Cassettes
L. Poirel
,
T. Lambert
,
Salih Türkoglü
,
E. Ronco
,
J. Gaillard
,
P. Nordmann
Antimicrobial Agents and Chemotherapy
2001
Corpus ID: 18731608
ABSTRACT Two clonally unrelated Pseudomonas aeruginosa clinical strains, RON-1 and RON-2, were isolated in 1997 and 1998 from…
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Highly Cited
1999
Highly Cited
1999
Semisynthetic aminoglycoside antibiotics: Development and enzymatic modifications
S. Kondo
,
K. Hotta
Journal of infection and chemotherapy : official…
1999
Corpus ID: 38981498
Abstract The critical resistance mechanisms of aminoglycoside antibiotics in bacteria of clinical importance are the enzymatic N…
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Highly Cited
1998
Highly Cited
1998
Synthesis of antibiotic-loaded interporous hydroxyapatite blocks by vacuum method and in vitro drug release testing.
M. Itokazu
,
W. Yang
,
T. Aoki
,
A. Ohara
,
N. Kato
Biomaterials
1998
Corpus ID: 23144479
Review
1997
Review
1997
The most frequent aminoglycoside resistance mechanisms--changes with time and geographic area: a reflection of aminoglycoside usage patterns? Aminoglycoside Resistance Study Groups.
G. Miller
,
F. Sabatelli
,
+5 authors
K. Shaw
Clinical infectious diseases : an official…
1997
Corpus ID: 25606389
The aminoglycoside resistance mechanisms revealed by two surveys in Europe and other countries have been compared to those…
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Review
1995
Review
1995
The changing nature of aminoglycoside resistance mechanisms and the role of isepamicin--a new broad-spectrum aminoglycoside. The Aminoglycoside Resistance Study Groups.
G. Miller
,
F. Sabatelli
,
L. Naples
,
R. Hare
,
K. Shaw
Journal of chemotherapy
1995
Corpus ID: 12886874
Aminoglycoside resistance mechanisms from recent studies were compared with those found in earlier studies in the USA and Europe…
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1993
1993
Alterations in membrane permeability induced by aminoglycoside antibiotics: studies on liposomes and cultured cells.
F. Van Bambeke
,
M. Mingeot-Leclercq
,
A. Schanck
,
R. Brasseur
,
P. Tulkens
European journal of pharmacology
1993
Corpus ID: 29997379
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