FAQ

isepamicin

Known as: D-Streptamine, O-6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-N1-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-, (S)-, (2S)-3-amino-N-((1R,2S,3S,4R,5S)-5-amino-4-[(6-amino-6-deoxy-D-glucopyranosyl)oxy]-2-{[3-deoxy-4-C-methyl-3-(methylamino)-L-arabinopyranosyl]oxy}-3-hydroxycyclohexyl)-2-hydroxypropanamide, N-(S-3-amino-2-hydroxypropionyl)gentamicin 
A broad-spectrum aminoglycoside antibiotic structurally related to gentamicin and amikacin. Isepamicin has activity similar to amikacin but with… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1984-2016
051019842016

Related topics

Related topics

5 relations

Broader (2)

Anti-Bacterial AgentsGentamicins

Narrower (3)

SCH21420Sch 21420isepamicin sulfate

Related mentions per year

Related mentions per year

1937-2018
19401960198020002020
isepamicin
Gentamicins
Anti-Bacterial Agents
isepamicin sulfate
Sch 21420
SCH21420

Papers overview

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2011
2011
Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates.
BACKGROUND the emergence of carbapenemases in Enterobacteriaceae is driving a search for therapeutic alternatives. We tested ACHN… (More)
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2005
2005
In vitro activities of tigecycline, ertapenem, isepamicin, and other antimicrobial agents against clinically isolated organisms in Taiwan.
This study evaluated the in vitro activities of tigecycline, ertapenem, isepamicin, and other comparators against 861 bacterial… (More)
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Highly Cited
2003
Highly Cited
2003
Acquisition of 16S rRNA methylase gene in Pseudomonas aeruginosa.
BACKGROUND Bacteria develop resistance to aminoglycosides by producing aminoglycoside-modifying enzymes such as acetyltransferase… (More)
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2003
2003
Multicentre surveillance of Pseudomonas aeruginosa susceptibility patterns in nosocomial infections.
OBJECTIVES To determine susceptibility rates and patterns in Pseudomonas aeruginosa strains isolated from nosocomial infections… (More)
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2001
2001
Characterization of Class 1 integrons from Pseudomonas aeruginosa that contain the bla(VIM-2) carbapenem-hydrolyzing beta-lactamase gene and of two novel aminoglycoside resistance gene cassettes.
Two clonally unrelated Pseudomonas aeruginosa clinical strains, RON-1 and RON-2, were isolated in 1997 and 1998 from patients… (More)
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2000
2000
Isepamicin versus amikacin for the treatment of acute pyelonephritis in children.
In this study we compared the efficacy and safety of isepamicin versus amikacin at a dose of 7.5 mg/kg i.v. q12h for 10-14 days… (More)
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1998
1998
Solution studies of isepamicin and conformational comparisons between isepamicin and butirosin A when bound to an aminoglycoside 6'-N-acetyltransferase determined by NMR spectroscopy.
NMR spectroscopy, combined with molecular modeling, was used to determine the conformations of isepamicin and butirosin A in the… (More)
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1996
1996
Population pharmacokinetic study of isepamicin with intensive care unit patients.
The pharmacokinetics (PK) of isepamicin, a new aminoglycoside, were studied in 85 intensive care unit (ICU) patients and were… (More)
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1995
1995
Evaluation of the efficacy and safety of isepamicin compared with amikacin in the treatment of nosocomial pneumonia and septicaemia.
Isepamicin is a new aminoglycoside antibiotic which possesses greater stability to aminoglycoside-inactivating enzymes compared… (More)
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Review
1995
Review
1995
Pharmacokinetics of isepamicin.
Isepamicin is a new aminoglycoside that has activity against many bacteria resistant to other aminoglycosides. The… (More)
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