isepamicin

Known as: D-Streptamine, O-6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-N1-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-, (S)-, (2S)-3-amino-N-((1R,2S,3S,4R,5S)-5-amino-4-[(6-amino-6-deoxy-D-glucopyranosyl)oxy]-2-{[3-deoxy-4-C-methyl-3-(methylamino)-L-arabinopyranosyl]oxy}-3-hydroxycyclohexyl)-2-hydroxypropanamide, N-(S-3-amino-2-hydroxypropionyl)gentamicin 
A broad-spectrum aminoglycoside antibiotic structurally related to gentamicin and amikacin. Isepamicin has activity similar to amikacin but with… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1984-2016
051019842016

Papers overview

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2011
2011
BACKGROUND the emergence of carbapenemases in Enterobacteriaceae is driving a search for therapeutic alternatives. We tested ACHN… (More)
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2005
2005
This study evaluated the in vitro activities of tigecycline, ertapenem, isepamicin, and other comparators against 861 bacterial… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Bacteria develop resistance to aminoglycosides by producing aminoglycoside-modifying enzymes such as acetyltransferase… (More)
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2003
2003
OBJECTIVES To determine susceptibility rates and patterns in Pseudomonas aeruginosa strains isolated from nosocomial infections… (More)
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2001
2001
Two clonally unrelated Pseudomonas aeruginosa clinical strains, RON-1 and RON-2, were isolated in 1997 and 1998 from patients… (More)
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2000
2000
In this study we compared the efficacy and safety of isepamicin versus amikacin at a dose of 7.5 mg/kg i.v. q12h for 10-14 days… (More)
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1998
1998
NMR spectroscopy, combined with molecular modeling, was used to determine the conformations of isepamicin and butirosin A in the… (More)
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1996
1996
The pharmacokinetics (PK) of isepamicin, a new aminoglycoside, were studied in 85 intensive care unit (ICU) patients and were… (More)
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1995
1995
Isepamicin is a new aminoglycoside antibiotic which possesses greater stability to aminoglycoside-inactivating enzymes compared… (More)
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Review
1995
Review
1995
Isepamicin is a new aminoglycoside that has activity against many bacteria resistant to other aminoglycosides. The… (More)
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