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isepamicin

Known as: D-Streptamine, O-6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-N1-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-, (S)-, (2S)-3-amino-N-((1R,2S,3S,4R,5S)-5-amino-4-[(6-amino-6-deoxy-D-glucopyranosyl)oxy]-2-{[3-deoxy-4-C-methyl-3-(methylamino)-L-arabinopyranosyl]oxy}-3-hydroxycyclohexyl)-2-hydroxypropanamide, N-(S-3-amino-2-hydroxypropionyl)gentamicin 
A broad-spectrum aminoglycoside antibiotic structurally related to gentamicin and amikacin. Isepamicin has activity similar to amikacin but with… 
National Institutes of Health

Papers overview

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2015
2015
OBJECTIVES Enterobacteriaceae clinical isolates showing amikacin resistance (MIC 64 to >256 mg/L) in the absence of 16S rRNA… 
Highly Cited
2011
Highly Cited
2011
BACKGROUND the emergence of carbapenemases in Enterobacteriaceae is driving a search for therapeutic alternatives. We tested ACHN… 
Review
2009
Review
2009
Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene have been implicated as a risk factor for stroke… 
Highly Cited
2001
Highly Cited
2001
ABSTRACT Two clonally unrelated Pseudomonas aeruginosa clinical strains, RON-1 and RON-2, were isolated in 1997 and 1998 from… 
Highly Cited
1999
Highly Cited
1999
  • S. Kondo, K. Hotta
  • Journal of infection and chemotherapy : official…
  • 1999
  • Corpus ID: 38981498
Abstract The critical resistance mechanisms of aminoglycoside antibiotics in bacteria of clinical importance are the enzymatic N… 
Review
1997
Review
1997
The aminoglycoside resistance mechanisms revealed by two surveys in Europe and other countries have been compared to those… 
Review
1995
Review
1995
Aminoglycoside resistance mechanisms from recent studies were compared with those found in earlier studies in the USA and Europe…