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isepamicin

Known as: D-Streptamine, O-6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-N1-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-, (S)-, (2S)-3-amino-N-((1R,2S,3S,4R,5S)-5-amino-4-[(6-amino-6-deoxy-D-glucopyranosyl)oxy]-2-{[3-deoxy-4-C-methyl-3-(methylamino)-L-arabinopyranosyl]oxy}-3-hydroxycyclohexyl)-2-hydroxypropanamide, N-(S-3-amino-2-hydroxypropionyl)gentamicin 
A broad-spectrum aminoglycoside antibiotic structurally related to gentamicin and amikacin. Isepamicin has activity similar to amikacin but with… 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (2)

Anti-Bacterial AgentsGentamicins

Narrower (4)

IsepacinSCH21420Sch 21420isepamicin sulfate
Isepamicin:Susc:Pt:Isolate:OrdQn:MIC

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
In vitro activity of aminoglycosides against clinical isolates of Acinetobacter baumannii complex and other nonfermentative Gram-negative bacilli causing healthcare-associated bloodstream infections…
2010
2010
Antibiotic and synergistic effect of Leu-Lys rich peptide against antibiotic resistant microorganisms isolated from patients with cholelithiasis.
1999
1999
Isepamicin in intensive care unit patients with nosocomial pneumonia: population pharmacokinetic-pharmacodynamic study.
A population approach was used to determine isepamicin pharmacokinetics in 196 intensive care unit patients treated for… 
1998
1998
Solution studies of isepamicin and conformational comparisons between isepamicin and butirosin A when bound to an aminoglycoside 6'-N-acetyltransferase determined by NMR spectroscopy.
NMR spectroscopy, combined with molecular modeling, was used to determine the conformations of isepamicin and butirosin A in the… 
1997
1997
Electric Fields and Interference Effects inside Noncentrosymmetric Multilayer Films at Electrode Surfaces from Electrochemically Modulated Surface Plasmon Resonance Experiments
The electric field profile inside a self-assembled noncentrosymmetric zirconium phosphonate (ZP) multilayer film at a gold… 
1997
1997
Synthesis, Spectroscopic Characterization, and Electro-Optical Properties of Noncentrosymmetric Azobenzene/Zirconium Phosphonate Multilayer Films
Ultrathin noncentrosymmetric nonlinear optical films based on zirconium phosphonate (ZP) self-assembled multilayers that… 
1997
1997
Which aminoglycoside or fluoroquinolone is more active against Mycobacterium tuberculosis in mice?
To identify the most active aminoglycoside or fluoroquinolone for the treatment of tuberculosis, the in vivo activities of four… 
1995
1995
Evaluation of the efficacy and safety of isepamicin compared with amikacin in the treatment of nosocomial pneumonia and septicaemia.
Isepamicin is a new aminoglycoside antibiotic which possesses greater stability to aminoglycoside-inactivating enzymes compared… 
1993
1993
Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats
Nephrotoxicity was more marked in rats receiving isepamicin at midlight than at middark. And, the once-daily administration at… 
Highly Cited
1990
Highly Cited
1990
Appearance of amikacin and tobramycin resistance due to 4'-aminoglycoside nucleotidyltransferase [ANT(4')-II] in gram-negative pathogens
Following the use of amikacin as the principal aminoglycoside at a Denver hospital, amikacin resistance appeared first in… 
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