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isaxonine

Known as: 2-Isopropylaminopyrimidine, 2-Pyrimidinamine, N-(1-methylethyl)-, Isopropylaminopyrimidine 
National Institutes of Health

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4 relations

Narrower (3)

N-isopropyl-amino-2-pyrimidine orthophosphateNerfactorisopropylamino-2-pyrimidine phosphate

Broader (1)

Pyrimidines

Papers overview

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1993
1993
Neurite outgrowth of neurons of rat dorsal root ganglia induced by new neurotrophic substances with guanidine group
1993
1993
Neurotropic pyrimidine heterocyclic compounds. I. The newly synthesized pyrimidine compounds promote neurite outgrowth of GOTO and neuro 2a neuroblastoma cell lines, and potentiate nerve growth…
From the study using cultured human and mouse neuroblastoma cells, we found that a new type of synthetic bicyclic pyrimidine… 
1989
1989
Presence of covalently bound metabolites on rat hepatocyte plasma membrane proteins after administration of isaxonine, a drug leading to immunoallergic hepatitis in man
Isaxonine and several other drugs transformed by cytochrome P‐450 into reactive metabolites apparently lead to immunoallergic… 
1988
1988
Therapeutic trial of isaxonine in duchenne muscular dystrophy
A randomized double‐blind therapeutic trial of isaxonine was completed over a 2‐year period for 20 ambulant boys with Duchenne… 
Highly Cited
1985
Highly Cited
1985
Drug‐induced hepatitis associated with anticytoplasmic organelle autoantibodies
A study from five hepatology units documenting 157 cases of drug‐induced hepatitis and a second study from a laboratory of… 
1985
1985
Interaction of vinblastine sulfate with artificial phospholipid membranes. A study by differential scanning calorimetry and spin labeling.
1984
1984
Mechanism for isaxonine hepatitis. I. Metabolic activation by mouse and human cytochrome P-450.
The metabolism of isaxonine was first investigated in mice. Incubation, under air, of [2-14C] isaxonine (1 mM) with mouse liver… 
1983
1983
Inhibition in vitro of the polymerization of tubulin by uremic middle molecules: corrective effect of isaxonine.
The polymerization of tubulin leads to the formation of microtubules which are one of the components of the axons of nerve cells… 
1983
1983
Microtubules and lymphocyte responses: Effect of colchicine and taxol on mitogen‐induced human lymphocyte activation and proliferation
The role of microtubules in mitogen‐induced human lymphocyte activation and proliferation was examined. The effect of colchicine… 
1980
1980
Muscle reinnervation enhanced by isaxonine in man.
None of the substances that accelerate nerve growth and motor function recovery under laboratory conditions has so far had useful… 
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