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iodothiouracil

Known as: 4(1H)-Pyrimidinone, 2,3-dihydro-5-iodo-2-thioxo-, 5-iodo-2-thiouracil, Jodthiouracilum 
National Institutes of Health

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Thiouracil
analogs & derivatives

Papers overview

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2009
2009
Thioamides as false melanin precursors: studies in murine melanomas.
Melanotic melanomas show a high rate of melanin synthesis. Foreign substances that are accepted as precursors in the formation of… 
1992
1992
Uptake of [131I]thiouracil in tumours of patients with disseminated malignant melanoma. A pilot study
Previous studies on mice carrying melanoma have shown that 5-iodo-2-thiouracil (ITU) is accumulated in the tumours due to its… 
1986
1986
Iodothiouracil as a melanoma localizing agent.
Thiouracil and various derivatives are selectively incorporated into the melanin pigment of melanomas during biosynthesis by… 
1986
1986
Thyroid hormones stimulate the release of hepatic lipase from cultured rat hepatocytes.
We have investigated the effects of triiodothyronine (T3) and thyroxine (T4) on the heparin-stimulated release of hepatic lipase… 
1983
1983
Potential radiopharmaceuticals for the detection of ocular melanoma. Part I. 5-iodo-2-thiouracil derivatives
The tissue distribution of a number of 5-[131I]-iodo-2-thiouracil derivatives was measured in Syrian golden hamsters with Greene… 
1954
1954
On the mode of action of iodothiouracil.
SINCE the synthesis of 5-halogeno-2-thiouracils by Barrett, Goodman, and Dittmer (1), the claim has been advanced that 5-iodo-2… 
1952
1952
Measurements of thyroid epithelium in glands prepared for surgery with iodothiouracil and with other antithyroid drugs.
THIS study was conducted in order to determine whether or not sodium-5-iodo-2-thiouracil,1 henceforth called Itrumil2 (R… 
1951
1951
Effect of 5-halogeno-2-thiouracil and of 6-methyl-5-iodo-2-thiouracil on oxygen consumption rats.
IN the preceding paper it was shown that the 5-halogeno-2-thiouracils are active antithyroid compounds in the rat as measured by… 
1951
1951
1-Methyl-2-mercaptoimidazole: a new active antithyroid agent.
SINCE thiouracil, the first antithyroid drug, became available, additional related compounds have received clinical trial. Chief… 
1949
1949
The antithyroid action of 5-iodothiouracil, 6-methyl-5-iodothiouracil, thiocytosine and (Ca) 4-n-propyl 6-oxypyrimidyl-2-mercaptoacetic acid.
AN interest in the antithyroid activity of iodothiouracil and thiocytosine was expressed in an earlier report (1) of observations… 
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