interstrand cross-link repair

Known as: ICL repair 
Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2017
051019952017

Papers overview

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2015
2015
DNA interstrand cross-links (ICLs) prevent strand separation during DNA replication and transcription and therefore are extremely… (More)
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Highly Cited
2011
Highly Cited
2011
DNA interstrand cross-links (ICLs) are toxic DNA lesions whose repair in S phase of eukaryotic cells is incompletely understood… (More)
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Highly Cited
2011
Highly Cited
2011
Interstrand cross-links (ICLs) block replication and transcription and thus are highly cytotoxic. In higher eukaryotes, ICLs… (More)
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2011
2011
DNA interstrand cross-links (ICLs) covalently link both strands of the DNA duplex, impeding cellular processes like DNA… (More)
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2011
2011
One of the major DNA interstrand cross-link (ICL) repair pathways in mammalian cells is coupled to replication, but the… (More)
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Highly Cited
2010
Highly Cited
2010
Fanconi anemia (FA) is caused by mutations in 13 Fanc genes and renders cells hypersensitive to DNA interstrand cross-linking… (More)
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Highly Cited
2009
Highly Cited
2009
Fanconi anemia is a human cancer predisposition syndrome caused by mutations in 13 Fanc genes. The disorder is characterized by… (More)
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2008
2008
Fanconi anemia (FA) is a cancer susceptibility syndrome characterized by defective DNA interstrand cross-link (ICL) repair. Here… (More)
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Highly Cited
2001
Highly Cited
2001
DNA interstrand cross-links (ICLs) block the strand separation necessary for essential DNA functions such as transcription and… (More)
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Highly Cited
2000
Highly Cited
2000
Interstrand DNA cross-link damage is a severe challenge to genomic integrity. Nucleotide excision repair plays some role in the… (More)
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