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Generation of human induced pluripotent stem cells from urine samples
Human induced pluripotent stem cells (iPSCs) have been generated with varied efficiencies from multiple tissues. Yet, acquiring donor cells is, in most instances, an invasive procedure that requiresExpand
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hTERT alone immortalizes epithelial cells of renal proximal tubules without changing their functional characteristics.
Telomere-dependent replicative senescence is one of the mechanisms that limit the number of population doublings of normal human cells. By overexpression of telomerase, cells of various origins haveExpand
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Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan
Several pathways modulating longevity and stress resistance converge on translation by targeting ribosomal proteins or initiation factors, but whether this involves modifications of ribosomal RNA isExpand
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miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging
Aging is a multifactorial process where deterioration of body functions is driven by stochastic damage while counteracted by distinct genetically encoded repair systems. To better understand theExpand
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miR-17–92 cluster: ups and downs in cancer and aging
The miR-17–92 cluster encoding 6 single mature miRNAs was identified a couple of years ago to contain the first oncogenic miRNAs. Now, one of these 6 miRNAs, miR-19 has been identified as the keyExpand
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Stable overexpression of miR-17 enhances recombinant protein production of CHO cells☆
Highlights • Transient overexpression of miR-17 and miR-17–92 cluster enhanced growth rate.• Biological effects of long term and stable overexpression of miRNAs in batch cultures were studied.•Expand
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Generation of induced pluripotent stem cells from urine.
Forced expression of selected transcription factors can transform somatic cells into embryonic stem cell (ESC)-like cells, termed induced pluripotent stem cells (iPSCs). There is no consensusExpand
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Differentially circulating miRNAs after recent osteoporotic fractures can influence osteogenic differentiation.
Osteoporosis is the consequence of altered bone metabolism resulting in the systemic reduction of bone strength and increased risk of fragility fractures. MicroRNAs (miRNAs) regulate gene expressionExpand
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High-Glucose–Triggered Apoptosis in Cultured Endothelial Cells
High ambient glucose concentration, linked to vascular complications in diabetes in vivo, modulates mRNA expression of fibronectin, collagen, tissue-type plasminogen activator, and plasminogenExpand
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Contributions of DNA interstrand cross-links to aging of cells and organisms
Impaired DNA damage repair, especially deficient transcription-coupled nucleotide excision repair, leads to segmental progeroid syndromes in human patients as well as in rodent models. Furthermore,Expand
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