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interleukin-12 receptor activity

Known as: IL-12 receptor activity, IL-12R 
Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl… 
National Institutes of Health

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interleukin-12 binding activity
interleukin-12 receptor

Papers overview

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Review
2004
Review
2004
Signaling by IL‐12 and IL‐23 and the immunoregulatory roles of STAT4
Summary:  Produced in response to a variety of pathogenic organisms, interleukin (IL)‐12 and IL‐23 are key immunoregulatory… 
Highly Cited
2004
Highly Cited
2004
Sustained IL-12 Signaling Is Required for Th1 Development 1
STAT4 is an essential transcription factor for Th1 cell development. IL-12 and IFN-α both activate STAT4, but with different… 
Highly Cited
2002
Highly Cited
2002
The Roles of IL-12 in Providing a Third Signal for Clonal Expansion of Naive CD8 T Cells1
Stimulation of an effective in vitro or in vivo response by naive CD8 T cells requires three signals: TCR engagement… 
Highly Cited
2001
Highly Cited
2001
Bidirectional Negative Regulation of Human T and Dendritic Cells by CD47 and Its Cognate Receptor Signal-Regulator Protein-α: Down-Regulation of IL-12 Responsiveness and Inhibition of Dendritic Cell…
Proinflammatory molecules, including IFN-γ and IL-12, play a crucial role in the elimination of causative agents. To allow… 
Highly Cited
1999
Highly Cited
1999
IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor.
IL-18 is a powerful inducer of IFN-gamma production, particularly in collaboration with IL-12. IL-18, like IL-12, also augments… 
Highly Cited
1998
Highly Cited
1998
Selective Expression and Functions of Interleukin 18 Receptor on T Helper (Th) Type 1 but not Th2 Cells
Interleukin (IL)-18 induces interferon (IFN)-γ synthesis and synergizes with IL-12 in T helper type 1 (Th1) but not Th2 cell… 
Highly Cited
1997
Highly Cited
1997
Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells
Highly Cited
1997
Highly Cited
1997
Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor.
Two chains of the IL-12R, IL-12Rbeta1 and IL-12Rbeta2, have recently been cloned. To determine the role of IL-12Rbeta1 in… 
Highly Cited
1994
Highly Cited
1994
Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130.
A cDNA encoding a human IL-12R subunit was isolated by expression cloning. This subunit is a 662 amino acid type I transmembrane… 
Highly Cited
1992
Highly Cited
1992
IL-12 receptor. II. Distribution and regulation of receptor expression.
IL-12 is a heterodimeric lymphokine that induces IFN-gamma production by resting PBMC, enhances the lytic activity of NK… 
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