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interleukin-12 receptor activity

Known as: IL-12 receptor activity, IL-12R 
Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl… Expand
National Institutes of Health

Papers overview

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Highly Cited
2002
Highly Cited
2002
IL-23 is a heterodimeric cytokine composed of the IL-12p40 “soluble receptor” subunit and a novel cytokine-like subunit related… Expand
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Highly Cited
2002
Highly Cited
2002
T helper type 1 (TH1) cell development involves interferon-γ (IFN-γ) signaling through signal transducer and activator of… Expand
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Highly Cited
2000
Highly Cited
2000
A novel sequence discovered in a computational screen appears distantly related to the p35 subunit of IL-12. This factor, which… Expand
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Highly Cited
1998
Highly Cited
1998
Interleukin-12 (IL-12) is a cytokine that promotes cell-mediated immunity to intracellular pathogens by inducing type 1 helper T… Expand
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Highly Cited
1998
Highly Cited
1998
Interleukin (IL)-18 induces interferon (IFN)-γ synthesis and synergizes with IL-12 in T helper type 1 (Th1) but not Th2 cell… Expand
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Highly Cited
1998
Highly Cited
1998
Synthetic oligodeoxynucleotides containing CpG dinucleotides (CpG-ODN) mimic the immunostimulatory qualities of bacterial DNA. We… Expand
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Highly Cited
1997
Highly Cited
1997
The developmental commitment to a T helper 1 (Th1)- or Th2-type response can significantly influence host immunity to pathogens… Expand
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Highly Cited
1997
Highly Cited
1997
Two chains of the IL-12R, IL-12Rbeta1 and IL-12Rbeta2, have recently been cloned. To determine the role of IL-12Rbeta1 in… Expand
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Highly Cited
1996
Highly Cited
1996
We have identified a cDNA from a human phytohemagglutinin-activated lymphoblast library encoding a protein that binds 125I… Expand
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Highly Cited
1995
Highly Cited
1995
Interleukin-12 (IL-12) is a cytokine that has regulatory effects on T and natural killer (NK) cells and is composed of two… Expand
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