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interleukin-12 receptor

Known as: Receptors, IL-12, Receptor, Interleukin 12, IL-12 Receptors 
Cell surface receptors for INTERLEUKIN-12. They exist as dimers of beta 1 and beta 2 subunits. Signaling from interleukin-12 receptors occurs through… 
National Institutes of Health

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IL12RB2 protein, humanInterleukin 12 Receptor Beta
In Bloodagonistsantagonists & inhibitorsaspects of radiation effects

Papers overview

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Highly Cited
2012
Highly Cited
2012
T-bet+ Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2
Highly Cited
2003
Highly Cited
2003
Role of IL-12 Receptor β1 in Regulation of T Cell Response by APC in Experimental Autoimmune Encephalomyelitis 1
IL-12 was thought to be involved in the development of experimental autoimmune encephalomyelitis (EAE), a Th1 cell-mediated… 
Highly Cited
2003
Highly Cited
2003
SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit.
Review
2003
Review
2003
Susceptibility to mycobacterial infections: the importance of host genetics
There is substantial evidence that host genetic factors are important in determining susceptibility to mycobacteria. Several… 
Highly Cited
2002
Highly Cited
2002
Nitric oxide preferentially induces type 1 T cell differentiation by selectively up-regulating IL-12 receptor β2 expression via cGMP
Nitric oxide plays an important role in immune regulation. We have shown that although high concentrations of NO generally were… 
Highly Cited
2000
Highly Cited
2000
The costimulatory effect of IL‐18 on the induction of antigen‐specific IFN‐γ production by resting T cells is IL‐12 dependent and is mediated by up‐regulation of the IL‐12 receptor β2 subunit
IL‐18 was originally described as a cytokine which induced IFN‐γ production by established Th1 cells in an IL‐12‐independent… 
Highly Cited
2000
Highly Cited
2000
Δ9-Tetrahydrocannabinol Treatment Suppresses Immunity and Early IFN-γ, IL-12, and IL-12 Receptor β2 Responses to Legionella pneumophila Infection1
The marijuana cannabinoid, Δ9-tetrahydrocannabinol (THC), suppresses immunity to Legionella pneumophila and development of Th1… 
Highly Cited
1999
Highly Cited
1999
The Natural Killer T (NKT) Cell Ligand α-Galactosylceramide Demonstrates Its Immunopotentiating Effect by Inducing Interleukin (IL)-12 Production by Dendritic Cells and IL-12 Receptor Expression on…
The natural killer T (NKT) cell ligand α-galactosylceramide (α-GalCer) exhibits profound antitumor activities in vivo that… 
Highly Cited
1997
Highly Cited
1997
Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4+ and CD8+ IFN-gamma-producing cells.
The role of IL-12 role in regulating Th1/Th2 balance is attributed in part to the ability of this cytokine to induce IFNgamma… 
Highly Cited
1992
Highly Cited
1992
IL-12 receptor. I. Characterization of the receptor on phytohemagglutinin-activated human lymphoblasts.
IL-12 is a 75-kDa heterodimeric cytokine composed of disulfide-bonded 35-kDa and 40-kDa subunits. Included among the biologic… 
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