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interleukin-12 receptor

Known as: Receptors, IL-12, Receptor, Interleukin 12, IL-12 Receptors 
Cell surface receptors for INTERLEUKIN-12. They exist as dimers of beta 1 and beta 2 subunits. Signaling from interleukin-12 receptors occurs through… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Antibody responses represent a key immune protection mechanism. T follicular helper (Tfh) cells are the major CD4(+) T-cell… Expand
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Highly Cited
2012
Highly Cited
2012
Summary Foxp3+ regulatory T (Treg) cells limit inflammatory responses and maintain immune homeostasis. Although comprised of… Expand
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Highly Cited
2003
Highly Cited
2003
IL-12 promotes the proliferation of T cells as well as NK cells and plays a critical role in induction of the Th1 differentiation… Expand
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Highly Cited
2003
Highly Cited
2003
IL-12 was thought to be involved in the development of experimental autoimmune encephalomyelitis (EAE), a Th1 cell-mediated… Expand
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Highly Cited
2003
Highly Cited
2003
Cell mediated immunity plays a critical role in human host defence against intracellular bacteria. In patients with unusual… Expand
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Highly Cited
2003
Highly Cited
2003
Th1-type immune responses, mediated by IL-12-induced IFN-gamma, protect the host from most viral infections. To investigate the… Expand
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Highly Cited
2002
Highly Cited
2002
Nitric oxide plays an important role in immune regulation. We have shown that although high concentrations of NO generally were… Expand
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Highly Cited
2000
Highly Cited
2000
IL-18 was originally described as a cytokine which induced IFN-gamma production by established Th1 cells in an IL-12-independent… Expand
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Highly Cited
1999
Highly Cited
1999
The natural killer T (NKT) cell ligand α-galactosylceramide (α-GalCer) exhibits profound antitumor activities in vivo that… Expand
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1992
1992
IL-12 is a 75-kDa heterodimeric cytokine composed of disulfide-bonded 35-kDa and 40-kDa subunits. Included among the biologic… Expand
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