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integrin activation

Known as: integrin complex activation, integrin complex assembly 
The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of… 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Regulation of integrin function and trafficking
Verstoringen in integrine functie vormen de basis van een aantal ziekten zoals longfibrose, nefrotisch syndroom en Kindler… 
Highly Cited
2010
Highly Cited
2010
Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation
Talin is a 270‐kDa protein that activates integrins and couples them to cytoskeletal actin. Talin contains an N‐terminal FERM… 
Highly Cited
2009
Highly Cited
2009
Structure of an integrin αIIbβ3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation
Heterodimeric integrin adhesion receptors regulate diverse biological processes including angiogenesis, thrombosis and wound… 
Highly Cited
2007
Highly Cited
2007
Mechanisms of Integrin–Vascular Endothelial Growth Factor Receptor Cross-Activation in Angiogenesis
The functional responses of endothelial cells are dependent on signaling from peptide growth factors and the cellular adhesion… 
Review
2004
Review
2004
Integrin activation
The ability of cells to regulate dynamically their adhesion to one another and to the extracellular matrix (ECM) that surrounds… 
Review
2002
Review
2002
Integrin activation takes shape
Integrins are cell surface adhesion receptors that are essential for the development and function of multicellular animals. Here… 
Highly Cited
2002
Highly Cited
2002
Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling
T cell receptor (TCR) stimulation activates the small GTPase Rap1A, which is reported to antagonize Ras signaling and induces T… 
Highly Cited
2001
Highly Cited
2001
Coupling of the TCR to Integrin Activation by SLAP-130/Fyb
SLAP-130/Fyb (SLP-76–associated phosphoprotein or Fyn-binding protein; also known as Fyb/Slap) is a hematopoietic-specific… 
Highly Cited
1997
Highly Cited
1997
Complementation of dominant suppression implicates CD98 in integrin activation
The integrin family of adhesion receptors are involved in cell growth, migration and tumour metastasis. Integrins are… 
Highly Cited
1996
Highly Cited
1996
Activated Conformations of Very Late Activation Integrins Detected by a Group of Antibodies (HUTS) Specific for a Novel Regulatory Region(355425) of the Common 1 Chain (*)
The very late activation antigens (VLA) or β1 integrins mediate cell attachment to different extracellular matrix proteins and… 
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