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integrin activation

Known as: integrin complex activation, integrin complex assembly 
The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Loss of talin 1 in platelets abrogates integrin activation , platelet aggregation , and thrombus formation in vitro and in vivo
Damage to the integrity of the vessel wall results in exposure of the subendothelial extracellular matrix, which triggers… 
Highly Cited
2005
Highly Cited
2005
Integrin Regulation by RhoA in Thymocytes1
The guanine nucleotide-binding protein Rho has essential functions in T cell development and is important for the survival and… 
Highly Cited
2005
Highly Cited
2005
Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity state.
Regulated changes in the affinity of integrin adhesion receptors ("activation") play an important role in numerous biological… 
Highly Cited
2004
Highly Cited
2004
Protein Phosphatase 1 Associates with the Integrin αIIb Subunit and Regulates Signaling*
Regulation of integrin activation occurs by specific interactions among cytoplasmic proteins and integrin α and β cytoplasmic… 
Highly Cited
2003
Highly Cited
2003
PEA-15 Binding to ERK1/2 MAPKs Is Required for Its Modulation of Integrin Activation*
Activation of Raf-1 suppresses integrin activation, potentially through the activation of extracellular signal-regulated kinases… 
2003
2003
Arg‐Gly‐Asp‐Ser peptide stimulates transforming growth factor‐β1 transcription and secretion through integrin activation
Extracellular matrix (ECM) components, through specific peptide motifs such as Arg‐Gly‐Asp (RGD), interact with integrins and can… 
2002
2002
Integrin Activation by Divalent Ions Affects Neutrophil Homotypic Adhesion
AbstractActivation of $$\beta _2$$ integrins on leukocytes, via receptor clustering or affinity changes, is a key step in the… 
Highly Cited
2001
Highly Cited
2001
Integrin Activation by Regulated Dimerization and Oligomerization of Platelet Endothelial Cell Adhesion Molecule (Pecam)-1 from within the Cell
Platelet endothelial cell adhesion molecule (PECAM)-1 is a 130-kD transmembrane glycoprotein having six Ig homology domains… 
Highly Cited
1998
Highly Cited
1998
The Death Effector Domain of PEA-15 Is Involved in Its Regulation of Integrin Activation*
Increased integrin ligand binding affinity (activation) is triggered by intracellular signaling events. A Ras-initiated mitogen… 
Highly Cited
1995
Highly Cited
1995
Energetics of Leukocyte Integrin Activation (*)
Cell adhesion mediated by leukocyte integrin CR3 (CD11b/CD18, αmβ2) may be rapidly modulated without changes in receptor number… 
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