insulin processing

The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1979-2018
0519792018

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Highly Cited
2013
Highly Cited
2013
Insulin secretion has a crucial role in glucose homeostasis, and failure to secrete sufficient insulin is a hallmark of type 2… (More)
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Highly Cited
2010
Highly Cited
2010
Zinc is highly concentrated in pancreatic beta cells, is critical for normal insulin storage and may regulate glucagon secretion… (More)
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Highly Cited
2010
Highly Cited
2010
OBJECTIVE Recent genome-wide association studies have revealed loci associated with glucose and insulin-related traits. We aimed… (More)
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2009
2009
Common variants in the TCF7L2 gene are associated with type 2 diabetes via impaired insulin secretion. One hypothesis is that… (More)
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2005
2005
Mutations in genes encoding HNF-4α, HNF-1α and IPF-1/Pdx-1 are associated with, respectively, MODY subtypes-1, -3 and -4… (More)
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2002
2002
BACKGROUND Islet transplantation studies with diabetic rodents frequently use treatment with diabetogens such as alloxan or… (More)
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2001
2001
Aims/hypothesis. Because oxidative stress has been suggested to be a significant contributing factor in the development of… (More)
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1990
1990
The effects of free fatty acids (FFA) on insulin receptor binding and processing (internalization, degradation, dissociation, and… (More)
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1990
1990
We have studied the intracellular processing of insulin in the rat hepatoma cell line Fao. Fao cells internalized cohorts of… (More)
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1987
1987
The processing and trafficking of insulin in cultured rat hepatocytes were studied. A time course of binding of radiolabeled… (More)
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