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insulin processing

The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form… 
National Institutes of Health

Papers overview

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2010
2010
Cellular reprogramming of human amniotic fluid cells to express insulin.
2006
2006
Examination of gene expression profile of functional human pancreatic islets after 2-week culture.
2005
2005
OP-142 gene expression profile of nonfunctional human pancreatic islets: predictors of transplant failure?
1997
1997
Insulin resistance does not change the ratio of proinsulin to insulin in normal volunteers.
Plasma glucose, insulin, and proinsulin concentrations were measured before and after an oral glucose challenge in 57 nondiabetic… 
1996
1996
Delayed intracellular dissociation of the insulin-receptor complex impairs receptor recycling and insulin processing in cultured Epstein-Barr virus-transformed lymphocytes from insulin-resistant…
SummaryInsulin-receptor internalization and processing are defective in insulin-resistant subjects. To assess the reversibility… 
1992
1992
In vitro processing of insulin for recognition by murine T cells results in the generation of A chains with free CysSH.
Studies on the processing of insulin as an Ag for the presentation to MHC class II-restricted T cells revealed that the amino… 
1987
1987
Intracellular insulin processing is altered in monocytes from patients with type II diabetes mellitus.
We studied total cell-associated A14-[125I]insulin radioactivity (including surface-bound and internalized radioactivity… 
1985
1985
Degradation of insulin by human fibroblasts: effects of inhibitors of pinocytosis and lysosomal activity.
1982
1982
Evidence for a direct effect of bacitracin on cell-mediated insulin degradation in isolated hepatocytes.
In freshly isolated hepatocytes, in which extracellular degradation of insulin was very low, the degradation velocity was first… 
1982
1982
Insulin degradation in 3T3-L1 adipocytes: role of the endocytic lysosomal pathway.
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