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insulin processing

The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Deregulation of mTOR complex 1 (mTORC1) signalling increases the risk for metabolic diseases, including type 2 diabetes. Here we… Expand
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Review
2014
Review
2014
Patients with established type 2 diabetes display both β-cell dysfunction and insulin resistance. To define fundamental processes… Expand
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Highly Cited
2013
Highly Cited
2013
Insulin secretion has a crucial role in glucose homeostasis, and failure to secrete sufficient insulin is a hallmark of type 2… Expand
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Highly Cited
2010
Highly Cited
2010
Aims/hypothesisZinc is highly concentrated in pancreatic beta cells, is critical for normal insulin storage and may regulate… Expand
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Highly Cited
2010
Highly Cited
2010
OBJECTIVE Recent genome-wide association studies have revealed loci associated with glucose and insulin-related traits. We aimed… Expand
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Review
2009
Review
2009
Research advances defining how zinc is transported into and out of cells and organelles have increased exponentially within the… Expand
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Highly Cited
2009
Highly Cited
2009
Aims/hypothesisCommon variants in the TCF7L2 gene are associated with type 2 diabetes via impaired insulin secretion. One… Expand
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2005
2005
Aims/hypothesisMutations in genes encoding HNF-4α, HNF-1α and IPF-1/Pdx-1 are associated with, respectively, MODY subtypes-1, -3… Expand
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Highly Cited
2001
Highly Cited
2001
Aims/hypothesis. Because oxidative stress has been suggested to be a significant contributing factor in the development of… Expand
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Highly Cited
2000
Highly Cited
2000
Fibroblast growth factor (FGF) signalling has been implicated in patterning, proliferation and cell differentiation in many… Expand
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