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insulin processing

The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Cellular reprogramming of human amniotic fluid cells to express insulin.
2000
2000
Colocalization of chaperone Cpn60, proinsulin and convertase PC1 within immature secretory granules of insulin-secreting cells suggests a role for Cpn60 in insulin processing.
Many of the mechanisms that control insulin processing and packaging by interaction with different elements along the secretory… 
Highly Cited
2000
Highly Cited
2000
C-peptide exerts cardioprotective effects in myocardial ischemia-reperfusion.
Ischemia followed by reperfusion in the presence of polymorphonuclear leukocytes (PMNs) results in cardiac dysfunction. C-peptide… 
1997
1997
Insulin resistance does not change the ratio of proinsulin to insulin in normal volunteers.
Plasma glucose, insulin, and proinsulin concentrations were measured before and after an oral glucose challenge in 57 nondiabetic… 
1993
1993
One-step site-directed mutagenesis of the Kex2 protease oxyanion hole
Highly Cited
1988
Highly Cited
1988
Properties of a human insulin receptor with a COOH-terminal truncation. I. Insulin binding, autophosphorylation, and endocytosis.
1987
1987
Intracellular insulin processing is altered in monocytes from patients with type II diabetes mellitus.
We studied total cell-associated A14-[125I]insulin radioactivity (including surface-bound and internalized radioactivity… 
1984
1984
Rapid transport of biologically intact insulin through cultured endothelial cells.
Mono A14-[125I]-iodoinsulin was incubated with cultured endothelial cells derived from bovine pulmonary arteries at physiologic… 
Highly Cited
1980
Highly Cited
1980
Cultured Hepatoma Cells as a Model System for Studying Insulin Processing and Biologic Responsiveness
SUMMARY Monolayer cultures of minimal deviation hepatoma cells (H4-II-E-C3′) bound and degraded insulin specifically, the… 
Highly Cited
1979
Highly Cited
1979
Effects of lysosomotropic agents on insulin interactions with adipocytes. Evidence for a lysosomal pathway for insulin processing and degradation.
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