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Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolism
Decreased availability of circulating NEFA may contribute to the observed improvement in the insulin sensitivity of EGP and glucose uptake following 6 weeks of moderate exercise.
A comparison of the effects of IGF‐I and insulin on glucose metabolism, fat metabolism and the cardiovascular system in normal human volunteers
- D. Russell-Jones, A. Bates, P. Sonksen
- Medicine, BiologyEuropean journal of clinical investigation
- 1 June 1995
There was no change in free fatty acids (FFA) and an increase (percentage change from pre‐infusion mean) in cardiac output, heart rate, and stroke volume and there were no significant changes in the cardiovascular variables.
The effects of growth hormone on protein metabolism in adult growth hormone deficient patients
Investigation of the actions of growth hormone treatment on protein metabolism in adult growth hormone deficient patients found an increase in lean body mass by an unknown mechanism.
The kinetics of insulin metabolism in diabetes mellitus.
The effect of atropine on the insulin release caused by oral and intravenous glucose in human subjects.
- J. R. Henderson, D. Jefferys, R. Jones, D. Stanley
- Medicine, BiologyActa endocrinologica
- 1 December 1976
Insulin release after oral glucose was significantly diminished by atropine, and this effect could not be ascribed to the drug delaying glucose absorption, but insulin release brought about by intravenous glucose was not altered byAtropine.
Use of a leucine clamp to demonstrate that IGF-I actively stimulates protein synthesis in normal humans.
- D. Russell-Jones, A. Umpleby, P. Sönksen
- Medicine, BiologyThe American journal of physiology
- 1 October 1994
It is concluded that IGF-I, under conditions of adequate substrate supply, directly increases protein synthesis in contrast to insulin, which exerts its anabolic action by reducing proteolysis.
Growth Hormone and Diabetes mellitus
The diabetogenic action of pituitary extracts containing growth hormone has been recognised for more than 60 years and the importance of growth hormone in the development and progression of diabetic r
Simulation of IGF-I pharmacokinetics after infusion of recombinant IGF-I in human subjects.
- M. Boroujerdi, R. Jones, P. Sönksen, D. Russell-Jones
- Biology, MedicineThe American journal of physiology
- 1 August 1997
The pharmacokinetics of recombinant human insulin-like growth factor I (IGF-I) were studied in four healthy volunteers by a 3-h infusion at a rate of 20 micrograms.kg-1.h-1. A compartmental model was…
Photoreactive insulin analogues used to characterise the insulin receptor.